Results 91 to 100 of about 4,149,654 (191)
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
"Don't stand up on unlevel ground": Care leavers' experiences of out-of-home care
Background: Children and young people in contact with child protection services often experience poorer life outcomes compared to their peers. Limited research exists on the reasons behind this disparity from the perspective of those with direct lived ...
Grieg, Hannah +3 more
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Dentistry JournalBackground: Children and young people (CYP) in care experience poorer physical health and overall wellbeing in comparison to their peers. Despite this, relatively little is known about what their oral health needs and behaviours are.
Joelle Booth +13 more
doaj +1 more source
Scottish Journal of Residential Child Care, 2020 This is a review of an overview report of a study conducted by Udayan Care in India with support from the United Nations Children's Fund (UNICEF), Tata Trusts and the five State Governments of Delhi, Gujarat, Karnataka, Maharashtra and Rajasthan.
Kenny McGhee
doaj +1 more source
Care leavers returns and quality reports
, 2016 Information is collected annually on care leavers aged 16-18 (OC1) and 19 (OC3)
Social Services and Public Safety (Northern Ireland) +1 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Turning Point Processes to Higher Education among Care Leavers
Social Work and Society, 2014 Children who grew up in care institutions encounter many difficulties in the years after leaving care, including challenges related to their low education achievements while they were still in care. Higher education is therefore hard and sometimes almost
Tehila Refaeli, Benjamin Strahl
doaj +2 more sources
Scottish Journal of Residential Child Care, 2014 A good education forms a cornerstone in the foundation for a positive future. For all children and young people it offers the basis for a later career, a potential route out of disadvantage and an environment in which to learn the crucial social skills ...
Victoria Hull
doaj +1 more source