Results 111 to 120 of about 3,999,164 (276)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Report di ricerca - Report della Sperimentazione Care leavers 2018 – 2023
Il Progetto Care Leavers è promosso dal Ministero del lavoro e delle politiche sociali nell’ambito del Fondo per la Lotta alla Povertà e all’Esclusione Sociale ed è realizzata in collaborazione con l’Istituto degli Innocenti.
Lucia Fagnini +15 more
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Children and young people in care until age 26: a must for improved outcomes
Scottish Journal of Residential Child Care, 2013 Care Leavers have the worst outcomes in our society across most social well-being indicators. This is even more shocking as they are as physically and mentally capable as any other Scot.
Duncan Dunlop
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
, 2023 Die vorliegende Bachelorarbeit gibt einen Überblick über die Lebenswelt von Care Leaver*innen, welche von Wohnungslosigkeit bedroht oder bereits wohnungslos sind und geht auf die Handlungsmöglichkeiten der Sozialen Arbeit in der Nachbetreuung ein.
Fleischmann, Johannes
core +1 more source
Social Work and Society, 2014 This paper reports on the findings of a PhD research project that set out to explore how young people leaving out of home care experienced and made sense of their transition to adulthood.
John Pinkerton, Carmel Rooney
doaj +2 more sources
Care leavers' engagement with services: motivational factors which sustain a positive relationship
Scottish Journal of Residential Child Care, 2011 According to Mitchell (1982), motivation refers to 'psychological processes that cause the arousal, direction and persistence of voluntary actions that are goal directed' (Mitchell 1982, p. 81).
Marina Amaral
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source