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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source

The effectiveness of care manager training in a multidisciplinary plan-do-check-adjust cycle on prevention of undesirable events among residents of geriatric care facilities. [PDF]

Geriatr Gerontol Int, 2021
Ikeda-Sonoda S, Okochi J, Ichihara N, Miyata H. +3 more
europepmc +1 more source

qbicsoftware/data-manager-app: 0.33.0

<p></p> <h2>What's Changed</h2> <h3>New Features </h3> <ul> <li>sort samples in edit spreadsheet like in the sample ...
wow-such-code +5 more
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source

[News Clip: City manager]

, 1959
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about Fort Worth's new city manager, L.
WBAP-TV (Television station : Fort Worth, Tex.)
core +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source

Integrating care in Singapore – The role of an enabling agency

International Journal of Integrated Care, 2014
Alvin Koh, Jason Yap
doaj +3 more sources

qbicsoftware/data-manager-app: 0.36.0

<p></p> <h2>What's Changed</h2> <h3>New Features </h3> <ul> <li>Highlight and provide Linkage to Onthology Class Iri ...
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collaborative care
depression
primary health care

medicine
integrated care
primary care

dementia
qualitative study