Results 181 to 190 of about 5,997,028 (302)

Beyond the Surgical Bill: Pharmacoeconomics and Real-World Utilization Across the Knee Osteoarthritis Care Pathway-A Critical Narrative Review. [PDF]

Healthcare (Basel)
Yapıcı F.
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Management of bone health in adult solid organ transplant recipients: a multidisciplinary care pathway. [PDF]

Clin Transplant Res
Saadi H, Lansang MC, El-Kaissi S, Khan L, Gossmann M, Budev MM, Abelson A, Arce K, Lindenmeyer CC.   +8 more
europepmc   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Impact of educational interventions on clinician knowledge, adherence, and satisfaction utilizing a CKD care pathway in primary care. [PDF]

BMC Nephrol
Green J, Chang A, Conti T, Kobylinski MS, Norfolk ER, Weimer M, Elbedewe A, Jhamb M.   +7 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Nursing-Led Support Across the Standard Care-Clinical Trial-Standard Care Pathway in Inflammatory Bowel Disease: A Review With Realist-Informed Interpretation. [PDF]

JGH Open
Napolitano D, Bozzetti M, Mora V, Pastore F, Caruso R, Guberti M, Amatucci V, Lopetuso LR, Laterza L, Scaldaferri F, Gasbarrini A.   +10 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Multidisciplinary Advanced Practice Nursing-Led Vascular Access Care Pathway in Patients with Cystic Fibrosis: A Practice-Based Descriptive Analysis. [PDF]

Healthcare (Basel)
Montserrat Gala AM, Fernández-Sáez J, Ayuso-Margañón R, Sillero Sillero A.   +3 more
europepmc   +1 more source

The realities of the Liverpool care pathway [PDF]

Nature Reviews Clinical Oncology, 2013
openaire   +2 more sources