Results 131 to 140 of about 9,674,845 (354)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Outpatient Parenteral Antimicrobial Therapy in a Tertiary Hospital in France: A Description of Service Models and Costs

Antibiotics
Background/Objectives: Outpatient parenteral antimicrobial therapy (OPAT) has been implemented throughout the world for the treatment of most infections.
Espérie Burnet, Alicia Le Bras, Guillaume Roucoux, Christian Dupont, Etienne Canouï, Clément Leclaire, Jérémie Zerbit, Pierre Régis Burgel, Clémence Martin, Isabelle Durand-Zaleski, Martin Duracinsky   +10 more
doaj   +1 more source

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. [PDF]

, 2016
BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines ...
Al-Awar, Rima, Babichev, Yael, Boutros, Paul C, Datti, Alessandro, Dickson, Brendan C, Gladdy, Rebecca A, Isaac, Methvin, Kabaroff, Leah, Prakesch, Michael, Sun, Ren X, Uehling, David, Venier, Rosemarie   +11 more
core   +2 more sources

Pathways to professionalism? Quality improvement, care pathways, and the interplay of standardisation and clinical autonomy.

Sociology of Health and Illness, 2017
Care pathways are a prominent feature of efforts to improve healthcare quality, outcomes and accountability, but sociological studies of pathways often find professional resistance to standardisation.
G. Martin, D. Kocman, T. Stephens, C. Peden, R. Pearse   +4 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Integrating care for neurodevelopmental disorders by unpacking control: A grounded theory study

International Journal of Qualitative Studies on Health & Well-Being, 2016
Background: To establish integrated healthcare pathways for patients with neurodevelopmental disorders (ND) such as autism spectrum disorder and attention-deficit hyperactivity disorder is challenging. This study sets out to investigate the main concerns
Gustaf Waxegård, Hans Thulesius
doaj   +1 more source

Rare disease care pathways in the EU: from odysseys and labyrinths towards highways

Journal of Community Genetics, 2021
Birutė Tumienė, H. Graessner
semanticscholar   +1 more source

Better organized care via care pathways: A multicenter study

PLoS ONE, 2017
An increased need for efficiency and effectiveness in today’s healthcare system urges professionals to improve the organization of care. Care pathways are an important tool to achieve this.
D. Seys, L. Bruyneel, S. Deneckere, S. Kul, Liz Van der Veken, R. van Zelm, W. Sermeus, M. Panella, K. Vanhaecht   +8 more
semanticscholar   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Screening for familial hypercholesterolaemia in primary care: Time for general practice to play its part [PDF]

, 2018
Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are ...
Brett, Tom, Gidding, Samuel, Qureshi, Nadeem, Watts, Gerald F   +3 more
core   +3 more sources