Results 51 to 60 of about 1,432,063 (219)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dual doppler dynamics: integrating femoral venous doppler and VExUS for predicting organ dysfunction in acute heart failure

Journal of Anesthesia, Analgesia and Critical Care
Background Heart failure (HF) leads to venous congestion (VC), leading to organ dysfunction. Traditional VC assessments include pulmonary artery catheterization and IVC ultrasound.
Vimal Bhardwaj, Abhishek Samprathi, Kingshuk Saha, Nicolas Orozco, Pramukh Hegde, Mohammed Nizamudin, Jose Chacko, Manu M. K. Varma, Andre Denault, Vikneswaran G., Philippe Rola, Arjun Alva   +11 more
doaj   +1 more source

Efficacy in the reduction ratios of middle molecules with the use of medium cut-off dialyzers and reduced dialysate flows: a cohort study

Frontiers in Medicine
IntroductionExpanded hemodialysis (HDx) enabled by Theranova increases the clearance of medium-sized molecules, improving clinical outcomes such as hospitalization and mortality. The objective of the study was to compare solute reduction ratios of medium-
Juan C. Castillo, Cesar Doria, Javier Cely, David Camargo, Viviana Orozco, Daniel Ducuara, Jasmin Vesga, Mauricio Sanabria, Angela Rivera, Bengt Lindholm, Peter Rutherford   +10 more
doaj   +1 more source

New Obligations and Shared Vulnerabilities: Reimagining Sustainability for Live-Able Worlds

Nordina: Nordic Studies in Science Education, 2019
STEM and sustainability education have become established concepts in what are understood to be progressive Canadian early childhood (EC) programs, often framed as a conduit for building more sustainable futures.
Narda Nelson, B. Denise Hodgins, Ildikó Danis   +2 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Chronic disease management perspectives of colorectal cancer survivors using the Veterans Affairs healthcare system: a qualitative analysis

BMC Health Services Research, 2018
Background Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the US. CRC survivors may have complex healthcare needs requiring care from both specialists and primary care.
Leah L. Zullig, Karen M. Goldstein, Hayden B. Bosworth, Sara M. Andrews, Susanne Danus, George L. Jackson, Dawn Provenzale, Morris Weinberger, Michael J. Kelley, Corrine I. Voils   +9 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Burnout amongst chiropractic faculty, practitioners, and trainees: a scoping review

Chiropractic & Manual Therapies
Objective The purpose of this scoping review was to summarize the literature pertaining to burnout and chiropractic. Methods A literature review was performed in accordance with Preferred Reporting of Systematic Reviews and Meta-Analysis Extension for ...
Brittni L. Partridge, Zachary E. Scott, Christopher B. Roecker, Sheryl A. Walters, Clinton J. Daniels   +4 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source