Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
Advanced Science, EarlyView.We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Advanced Science, EarlyView.We introduce a new membrane‐active antifungal design, Gua‐SMACS‐16, that exhibits high potency and single‐species selectivity for C. tropicalis while sparing other close species in the Candida genus. Moreover, when combining with caspofungin, a clinical antifungal drug inhibiting 1,3‐β‐glucan synthase, they exhibit ultra‐strong synergy across a panel ...
Tianjiao Dai +8 more
wiley +1 more source
Increasing Career Decision-Making Self-efficacy Through Solution-Focused Career Counseling
Bisma The Journal of CounselingThe emergence of various new jobs means individuals must be confident in their career decisions. The problem for high school students is that students tend to need more confidence in deciding on the right career direction.
Ryan Hidayat Rafiola +3 more
doaj +1 more source
University students' career adaptability as a mediator between cognitive emotion regulation and career decision-making self-efficacy. [PDF]
Front Psychol, 2022 Lee A, Jung E.
europepmc +1 more source
Advanced Science, EarlyView.SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang +8 more
wiley +1 more source
Development and testing of the career decision-making self-efficacy scale for nursing students: a methodological study. [PDF]
BMC Nurs, 2022 Jung YM, Yoo IY.
europepmc +1 more source
Neuromorphic Near‐Sensor and In‐Sensor Computing Enabled by Next‐Generation Material‐Based Sensors
Advanced Science, EarlyView.This Review presents a structural framework that classifies neuromorphic sensing into near‐sensor and in‐sensor architectures, clarifying physical coupling between sensing and computation. The framework connects neural and synaptic device functions with recent advances in optical, mechanical, and chemical sensing, compares energy consumption and ...
Su Yeon Jung +7 more
wiley +1 more source
Advanced Science, EarlyView.A non‐canonical core transcriptional regulatory circuit, composed of ID3, SMAD3, and NR2F2, drives Osimertinib resistance in non‐small cell lung cancer through super‐enhancer‐mediated activation of EPAS1, which couples neuroendocrine differentiation with ferroptosis evasion.
Aochu Liu +15 more
wiley +1 more source
The Role of Family Influence and Academic Satisfaction on Career Decision-Making Self-Efficacy and Happiness. [PDF]
Int J Environ Res Public Health, 2021 Koçak O +5 more
europepmc +1 more source
Career choice anxiety and career decision-making: As moderated by career self-efficacy
, 2017 The objective of the current study is to determine the influence of CSA on CDM and to determine if CSE moderates this relationship. A total of 155 undergraduates and fresh graduates from various universities in Metro Manila participated in this study. By
Bocanegra, Maria Paz Isabela H. +3 more
core