Results 121 to 130 of about 12,816,081 (245)

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

The Effect of Career-Related Course on the Career Decision Making Self-efficacy of Senior University Students

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi
The aim of this study is to evaluate the effect of an “Interviewing Skills in Career Counseling” course on the level of career decision-making self-efficacy of senior university students.
Özlem Ulaş Kılıç
doaj   +1 more source

CAREER DECISION-MAKING SELF-EFFICACY: CAREER GOAL DISCREPANCY DAN RESILIENSI

Proyeksi
Kesulitan mahasiswa dalam menentukan pilihan karier seringkali berkaitan dengan rendahnya career decision-making self-efficacy (CDMSE). Kondisi ini menyebabkan mahasiswa mengalami tekanan dalam menentukan arah kariernya. Penelitian ini dilakukan untuk menguji hubungan antara career goal discrepancy dan resiliensi dengan CDMSE.
Laila Moza Aurelia, Dian Kinayung, Arini Widyowati   +2 more
openaire   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

Self-authorship and creative industries workers’ career decision-making

, 2018
Career decision-making is arguably at its most complex within professions where work is precarious and career calling is strong. This article reports from a study that examined the career decision-making of creative industries workers, for whom career ...
Dawn Bennett (23319937), S. Hennekam (23412949)   +1 more
core  

Pyruvate Kinase M2‐Mediated H3K9 Lactylation and XBP1 Signaling Positive Feedback Loop Facilitates CD4+ T Cell Spinal Recruitment and Central Sensitization in Rheumatoid Arthritis

Advanced Science, EarlyView.
In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang, Xiaoxuan Zhao, Xiao Ma, Mengjia Zheng, Junjun Wen, Yujie Li, Yue Wu, Yun Zhang, Jie Yu, Charles R. Ashby Jr, Chengping Wen   +10 more
wiley   +1 more source

Proactive Personality, Career Decision Making, and Self-Efficacy among University Students

The current research focused on exploring how proactive personality is correlated with self efficacy in career decision-making among university students and whether or not proactive personality was a predictor of self-efficacy in career decision-making ...
Mariyam Aslam, Muntaha Zia
core   +1 more source

Emotional intelligence leadership and career decision-making self-efficacy among college students in China: The mediating role of social support and proactive personality.

PLoS ONE
Student leadership education is a significant component of global education that positively impacts college students' employment. This study examined the relationship between emotional intelligence leadership and career decision-making self-efficacy ...
Kaida Wang, Jun Hu, Xiao Yang, Hua Ding, Hailun Huang, Zhanlu Xu   +5 more
doaj   +1 more source

Working on Stories to Enhance Career Decision Makings Self-Efficacy

International Journal of Psychological Studies, 2019
This article considers the potential complementarity of traditional career assessment and more recent narrative approaches -in particular narrative career counseling and story telling approach- to career counseling in terms of theory and practice. It describes an Integrated Qualitative Structured Interview to construct stories about the four sources of
openaire   +2 more sources

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source