Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Soft Skills for Employment in Morocco: A Value Over or Equal to the Technical Know-how?
Soft skills comprise a blend of social abilities, interpersonal communication, knowledge, and character traits that enhance individuals' social and professional lives.
Mohamed Ezzaidi
doaj +1 more source
Productive partnerships: cross-departmental connections in a tertiary context [PDF]
This chapter describes the development of productive and collegial relationships in a cross-departmental capacity-building project. The MMTP built on a first year experience program-the FYI Program (using the acronym that could stand for First Year ...
Henderson, Robyn, Noble, Karen
core
Copy Number Variants and Their Association With Intracerebral Hemorrhage Risk: A Case–Control Study
ABSTRACT Introduction Intracerebral Hemorrhage (ICH) is a leading cause of morbidity and mortality worldwide and lacks effective therapeutic interventions. Despite previous studies, the genetic underpinnings of ICH remain poorly understood. We sought to investigate the role of copy number variants (CNVs) in ICH pathophysiology to identify novel ...
Savvina Prapiadou +12 more
wiley +1 more source
Examining the Overlapping Traits of Athletes and Entrepreneurs Through a Series of Case Studies [PDF]
Today’s psychologists have paid close attention to personality and how it can affect many areas of a person’s life. From career success to criminal behavior psychologists continuously are trying to define key characteristics that may be contributing ...
Quast, Harrison M
core +1 more source
The Relationship Between Inflammation and Central Nervous System in Multiple Sclerosis
ABSTRACT Aim Multiple sclerosis is an autoimmune demyelination disease that is seen especially in the young population and has a progressive course, causing motor, sensory, and cognitive deficits. In the literature, the pathogenesis of MS disease and the interconnection between the immune and central nervous system in the disease have not been fully ...
Gamze Ansen +5 more
wiley +1 more source
Profiles of first-year students of tourism and recreation at the University of Łódź Faculty of Geographical Sciences in the academic year 2010/11 [PDF]
Notatka naukowa, tekst równol.
Maro-Kulczycka, Marta
core +1 more source
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo +9 more
wiley +1 more source
Monica Pellerone,1 Alessia Passanisi,1 Mario Filippo Paolo Bellomo2 1Faculty of Human and Social Science, “Kore” University of Enna, Enna, 2Credito Emiliano Bank, Piazza Armerina, Italy Background: Forming one’s identity is thought to ...
Pellerone M, Passanisi A, Bellomo MFP
doaj

