Results 261 to 270 of about 1,167,212 (331)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Factors associated with career decision-making difficulties among undergraduate nursing students: a latent profile analysis. [PDF]

Front Med (Lausanne)
Zhou H, Huang L, Fu Z, Li L, Huang Z, Zhang J, Tang M, Wang X, Sui W, Zhuang Y.   +9 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Weaving the future: Maturity and key factors in women's cultural entrepreneurship in Colombia's artisan sector. [PDF]

PLoS One
Mendivil-Hernández P, Alvis-Arrieta J, Garcés-Prettel M.   +2 more
europepmc   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

The impact of creative thinking on organizational maturity and the mediating role of experiential learning among knowledge management professionals. [PDF]

Sci Rep
Nasabi NA, Yusefi AR, Bordbar N.
europepmc   +1 more source

Modelling analysis of career control sources and critical thinking among nursing undergraduates during the epidemic: a cross-sectional survey study. [PDF]

BMJ Open
Xiao Y, Zhao L, Song M, Wei X, Guo Y, Wan J, Li W, Huang C.   +7 more
europepmc   +1 more source

Mental health in elite and youth athletes: emerging strategies and evidence-based trends: a narrative review. [PDF]

Ann Med Surg (Lond)
Khan I, Dewan ZA, Akhtar M, Sawaira F, Ur Rehman H, Rao T, Imran F, Abbas A, Malik T, Alokozay E.   +9 more
europepmc   +1 more source

Relationships between stress indicators and sexual development during onset of maturity in broiler breeder roosters. [PDF]

Poult Sci
Caliva JM, Marozzi A, Nobili MC, Guidobaldi HA, Marin RH, Kembro JM.   +5 more
europepmc   +1 more source

A Shared Humanity. [PDF]

Fam Med
Spencer J.
europepmc   +1 more source