Results 121 to 130 of about 132,276,789 (252)

Careers in Science Journalism and Writing. [PDF]

Cold Spring Harb Perspect Biol, 2017
Pearson H.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

At the Crossroads of Science and Society: Careers in Science Policy. [PDF]

Cold Spring Harb Perspect Biol, 2018
Patterson AP, Groesch ME, Shipp AC, Viggiani CJ.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Balancing Earth science careers in an unequal world

Communications Earth & Environment
Unequal research experiences among Earth scientists from around the world are an obstacle to achieving sustainability. We assess challenges and propose ways to balance the careers of early- and mid-career researchers in the Global South with those in the
Nadia Testani, Lucía M. Cappelletti, Leandro B. Díaz, Camila Prudente, Valentina Rabanal, Julia Mindlin, Reyk Börner, Divya David T, Ismaila Diallo, Inés M. Leyba, Marisol Osman, Andrés Tangarife-Escobar   +11 more
doaj   +1 more source

Scientists who leave research to pursue other careers in science are still scientists. [PDF]

Proc Natl Acad Sci U S A, 2019
Hanlon SM.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Careers in Science and Grant Administration: View from the National Institutes of Health. [PDF]

Cold Spring Harb Perspect Biol, 2018
Zatz M, Dupere S.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Taking early careers global: Global employers’ insights survey [PDF]

The Taking early careers global: Global employers’ insights survey was conducted from 20th December 2023 to 29th January 2024 and received 85 responses from global employers across a wide range of sectors.
Lai, K. T., Hooley, T., International Network of Employers and University Careers Services, Vahidi, G.   +3 more
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