Results 41 to 50 of about 132,276,789 (252)
Comparative Failure in Science
Grounded Theory Review: An International Journal, 2017 A perennial problem for some scientists is their feeling of comparative failure as scientists. This problem becomes clearer if we consider two major sources of this feeling that are inherent in the vary nature of scientific work.
Barney Glaser, PhD, Hon Phd
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Factors that influence student pursuit of science careers; the role of gender, ethnicity, family and friends [PDF]
, 2011 This study adds to a body of research reporting on pupils’ choices and outcomes in relation to science. The article reports on 536 Scottish pupils’ perceptions regarding reported intention to choose careers in science, with further analysis in terms of ...
Rodrigues, Susan +2 more
core
eLife, 2019 After acknowledging that power differentials exist, can scientists find inspiration to persevere anyway?
Indira M Raman
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
National Careers Council, an aspirational nation: creating a culture change in careers provision; Careers England Policy Commentary 21 [PDF]
, 2013 This is the twenty-first in an occasional series of briefing notes on key policy documents related to the future of career guidance services in England.
Hooley, Tristram
core
Educational mismatch and the careers of scientists [PDF]
, 2011 Previous research confirms that many employees work in jobs not well matched to their skills and education, resulting in lower pay and job satisfaction.
Keith A. Bender +6 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source