Results 111 to 120 of about 239,134 (285)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The social organisation of COVID-19: experiences and consequences for older people

Cogent Gerontology
On 5 May 2023, the World Health Organization (WHO) declared that the SARS-CoV-2 virus (COVID-19) no longer constituted a global health emergency (WHO, 2023).
Chris Phillipson, Camilla Lewis, Amanda Grenier   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Carers' experiences and perspectives of the use of anticholinergic medications in people living with dementia: Analysis of an online discussion forum

Health Expectations
Introduction There is concern about the use of anticholinergic medications in people living with dementia (PLWD). Such medicines may increase cognitive decline and may be associated with higher mortality in PLWD who take these medicines.
Bara'a Shawaqfeh, Carmel M. Hughes, Bernadette McGuinness, Heather E. Barry   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

PERANAN WANITA MELAYU DALAM PROSES PENJAGAAN IBU BAPA TUA: DILEMA DAN CABARAN DALAM ERA GLOBALISASI (ROLES OF MALAY WOMEN IN THE PROCESS OF CARING FOR ELDERLY PARENTS: DILEMMA AND CHALLENGES IN THE ERA OF GLOBALISATION) [PDF]

Kajian Malaysia, 2010
Peningkatan bilangan warga tua (60 tahun ke atas) di beberapa negara Asia Tenggara termasuk Malaysia dan Indonesia semakin membimbangkan. Kepadatan penduduk warga tua di Malaysia dijangka akan meningkat kepada 2.2 juta orang pada tahun 2020.
Khadijah Alavi, Rahim M. Sail
doaj  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Book review: Barnes, M., Brannelly, T., Ward, L., Ward, N. (2015). Ethics of care: Critical advances in international perspectives. Policy Press. 286pp, ISBN: 9781447316541

Scottish Journal of Residential Child Care, 2016
This edited volume provides a comprehensive conceptual and practical exploration of ethics of care from a diverse range of perspectives and contexts. The market place for such a book in not over-crowded and this allows the editors to rightly lay claim to
Richard Ingram
doaj   +1 more source

Reducing gender inequalities to create a sustainable care system [PDF]

, 2008
Women mainly provide family care, but as women’s economic opportunities increase they will not continue to bear the costs of providing care unaided. To create a sustainable care system, care and carers must be better supported and more highly valued to ...
Himmelweit, Susan, Land, Hilary
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