Results 71 to 80 of about 58,576 (242)

Patient and Carer Understandings and Experiences of Living With Type 2 Diabetes in India

Health Expectations
Background The prevalence of type 2 diabetes (T2D) is rapidly increasing in India. Evidence suggests that adherence to both pharmacological and nonpharmacological treatment regimens combined with support from carers may help in the optimal management of ...
Rahul Krishna Puvvada, Joanne Marcucci, Clarice Tang, Jency Thomas, Peter Higgs, Ramesh Madhan, Sabrina Gupta   +6 more
doaj   +1 more source

Common mental disorder among family carers of demented older people in Brazil

Dementia & Neuropsychologia
Objective: Population aging is a global phenomenon associated with a rising prevalence of chronic degenerative diseases such as dementia. Dementia poses a challenge not only for patients but also their family caregivers who, in exercising this role, are ...
Evelise Saia Rodolpho Duarte, Liciane Vaz de Arruda Silveira, Vanessa de Albuquerque Cítero, Alessandro Ferrari Jacinto   +3 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Building Better Website Resources: What People Diagnosed with Sarcoma and Their Carers Want to Know

Current Oncology
Sarcomas are a group of aggressive cancers, primarily affecting the soft tissue or bone [...]
Georgia K. B. Halkett, Jenny Davies, Chloe Maxwell-Smith, Connor Farnell, Mandy Basson, Tania Rice-Brading, Mariana S. Sousa, Janene Sproul, Helen M. De Jong, Haryana M. Dhillon, Joanna Elizabeth Fardell, Moira O’Connor   +11 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Carers' experiences and perspectives of the use of anticholinergic medications in people living with dementia: Analysis of an online discussion forum

Health Expectations
Introduction There is concern about the use of anticholinergic medications in people living with dementia (PLWD). Such medicines may increase cognitive decline and may be associated with higher mortality in PLWD who take these medicines.
Bara'a Shawaqfeh, Carmel M. Hughes, Bernadette McGuinness, Heather E. Barry   +3 more
doaj   +1 more source

The social organisation of COVID-19: experiences and consequences for older people

Cogent Gerontology
On 5 May 2023, the World Health Organization (WHO) declared that the SARS-CoV-2 virus (COVID-19) no longer constituted a global health emergency (WHO, 2023).
Chris Phillipson, Camilla Lewis, Amanda Grenier   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

PERANAN WANITA MELAYU DALAM PROSES PENJAGAAN IBU BAPA TUA: DILEMA DAN CABARAN DALAM ERA GLOBALISASI (ROLES OF MALAY WOMEN IN THE PROCESS OF CARING FOR ELDERLY PARENTS: DILEMMA AND CHALLENGES IN THE ERA OF GLOBALISATION) [PDF]

Kajian Malaysia, 2010
Peningkatan bilangan warga tua (60 tahun ke atas) di beberapa negara Asia Tenggara termasuk Malaysia dan Indonesia semakin membimbangkan. Kepadatan penduduk warga tua di Malaysia dijangka akan meningkat kepada 2.2 juta orang pada tahun 2020.
Khadijah Alavi, Rahim M. Sail
doaj