Results 161 to 170 of about 1,886,374 (304)

Kinesin-1 conformational dynamics are controlled by a cargo-sensitive TPR switch. [PDF]

Elife
Shukla S, Cross JA, Kish M, Yadav SKN, Weijman JF, O'Regan L, Mantell J, Borucu U, Leng X, Schaffitzel C, Phillips JJ, Woolfson DN, Dodding MP.   +12 more
europepmc   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Exosomes serve as natural nanocarriers targeting cancer stem cells to advance precision oncology. [PDF]

Discov Oncol
AlRamadneh TN, Aditya FA, Abdulsahib WK, Jasim IK, Malathi H, Nayak PP, Alex Anand D, Mukherjee G, Sinha A, Hayitova M.   +9 more
europepmc   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Bidirectional Interactions Between Nanomaterials and Extracellular Vesicles: Molecular Insights and Translational Implications. [PDF]

Int J Nanomedicine
Sa J, Lv Y, He J, Wang K, Zhou J.
europepmc   +1 more source

Vat Polymerization 3D Printing for Controlled Drug Release Applications

Advanced Materials Technologies, EarlyView.
ABSTRACT Vat polymerization (VP) 3D printing, a light‐based additive manufacturing technique, has emerged as a promising technique for fabricating complex drug delivery systems with high precision and spatial resolution. This layer‐by‐layer manufacturing process enables the creation of intricate geometries and customizable architectures, which are ...
Hafiz Busari, O. Thompson Mefford, M. Aaron Vaughn   +2 more
wiley   +1 more source

IRES-cargo interplay structurally modulates circular RNA translation. [PDF]

Cell Res
Huang Y, Chen YQ, Lou SY, Gao X, Liu YX, Zhang YL, Nan F, Chen LL, Yang L.   +8 more
europepmc   +1 more source

Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity Analysis

Advanced Materials Technologies, EarlyView.
The hydroporator platform employs controlled hydrodynamic deformation for efficient mRNA and CRISPR/Cas9 delivery into primary human T cells, enabling allogeneic CAR‐T cell manufacturing. It preserves cell functionality and drives potent gene editing, CAR expression, and tumor cytotoxicity, while feature‐based analysis links these functional outcomes ...
Soohyun Jeon, Sein Kim, Hyun‐Young Kim, Duck Cho, Sungsu Park, Seohyun Kim, Aram J. Chung   +6 more
wiley   +1 more source

Subcellular nanoparticle trafficking investigated with label-free, live cell imaging. [PDF]

Nanoscale Horiz
Nelson EB, Covarrubias G, Nabar N, Gomerdinger VF, Scott A, Hammond PT, Straehla JP.   +6 more
europepmc   +1 more source

Dynamic Current Routing in Conductive Liquid Crystal Elastomers for Complex Deformation Actuators

Advanced Materials Technologies, EarlyView.
This work introduces a novel actuation control strategy in which electrical stimulation generates localized Joule heating in conductive liquid crystal elastomer (LCE) surfaces, enabling complex 3D deformations from a single homogeneous surface without preprogramming.
Gloria PouWai Lei, Morgan Barnes, Thomas George Thuruthel   +2 more
wiley   +1 more source