Results 271 to 280 of about 2,024,000 (335)

PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2. [PDF]

Commun Biol
Yang Y, Thomas L, Chen K, Villar-Pazos S, Haffey WD, D'Agostino A, Fanelli K, Choi YJ, Rathi V, Matlapudi MS, Greis KD, Thomas G.   +11 more
europepmc   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Rules of the road: how to turn off kinesin motors. [PDF]

Biochem J
Tan Z, Missman A, Cianfrocco MA.
europepmc   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source

Regulation of extracellular vesicles for protein secretion in <i>Aspergillus nidulans</i>. [PDF]

Microb Cell
Pope RE, Ballmann P, Whitworth L, Prade RA.   +3 more
europepmc   +1 more source

Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility

Advanced Science, EarlyView.
We identify an antagonistic ubiquitin circuit that controls cellular permissiveness to multiple coronaviruses. The deubiquitinase USP7 stabilizes the epigenetic regulator KDM6A to upregulate viral receptors, while the E3 ligase RNF40 degrades KDM6A by catalyzing K6/K11‐ubiquitin chains of KDM6A for autophagic degradation.
Meng‐Zhuo Huang, Zhong‐Yuan Yang, Shi Wang, Yan Ge, Lan Lin, Mia Madel Alfajaro, Renata B. Filler, Wan‐Yao Song, Ming‐Zhu Kong, Jin Wei   +9 more
wiley   +1 more source

CSPG4⁺ extracellular vesicles carry fibronectin and interleukin-11 and reflect radiographic severity in knee osteoarthritis. [PDF]

Osteoarthr Cartil Open
Zhang X, MacFarlane LA, Huebner JL, Tao JJ, Katz JN, Kraus VB.   +5 more
europepmc   +1 more source

Extracellular Vesicles in Drug Delivery: From Quality Assurance to Therapeutic Application. [PDF]

Int J Nanomedicine
Zhang K, Fang J.
europepmc   +1 more source

Encapsulins in Terpene Biosynthesis: Enzyme Nanoreactors in Bacterial Secondary Metabolism. [PDF]

Biochemistry
Andreas MP, Giessen TW.
europepmc   +1 more source