Results 31 to 40 of about 407 (228)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The calm before the storm: carlist and neocatholics in the Valencian country between 1849 and 1868 | La calma antes de la tempestad: carlistas y neocatólicos en el País Valenciano entre 1849 y 1868

open access: yesPasado y Memoria, 2012
Between 1849 and 1868 the Valencian carlism lived a dark age, in which its activity was very small, due to the failures of its previous revolts and the support to moderantism of many former carlists. At the same time, it emerged an absolutist group which
Antonio Caridad Salvador
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

The uneven space distribution of first carlism: a quantitative approach [PDF]

open access: yes, 2018
Uno de los aspectos peor explicados del carlismo es su desigual distribución territorial. Tradicionalmente se ha explicado esta desigualdad aludiendo al distinto impacto de la crisis económica en cada territorio.
Caridad, Antonio
core  

Ideological and Artistic Originality of M. Vayreda’s Novel “New Blood”: from Carlism to Conservative Catalanism [PDF]

open access: yes
Статья поступила в редакцию 09.02.2024 г.Статья посвящена роману каталонского писателя М. Вайреды «Новая кровь» (1900). Анализируется отражение политических взглядов автора в тексте произведения. М.
Tereshchuk, A. A.   +1 more
core   +1 more source

La eclosión de la prensa satírica en España (1868-1874)

open access: yesEl Argonauta Español
The birth and consolidation of the satirical press in the revolutionary period of 1868-1874 constitute the central theme of this work. Turned into an instrument of propaganda by the liberals since 1808, the satirical newspapers soon showed their ability ...
Antonio Laguna Platero   +1 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

La prensa carlista y falangista durante la Segunda República y la Guerra Civil (1931-1937)

open access: yesEl Argonauta Español
This article seeks to address a comparative study of the press and propaganda structures of Spanish traditionalism (carlism) and fascism (Phalange), who where the main political organization that since April 1937 formed the single party Falange Española ...
Eduardo González Calleja
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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