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Therapeutic potential of L-Carnitine in improving adenine-induced hematological abnormalities in rats: A preclinical pharmacological study. [PDF]
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Effect of Carnitine Analogs on Carnitine Acetyltransferase
Journal of Pharmaceutical Sciences, 1980Carnitine analogs with various substituents on the nitrogen were tested for their effect on carnitine acetyltransferase from rat sperm and pigeon breast. A radiometric assay was used to measure the formation of acetylcarnitine in the presence of other enzymes that competed for acetyl coenzyme A in the sperm preparation.
M R, Boots +3 more
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Microdetermination of (−)carnitine and carnitine acetyltransferase activity
Analytical Biochemistry, 1977Abstract A method for the determination of picomole amounts of total (−)carnitine and free (−)carnitine in the presence of short-chain acyl(−)carnitines is described. The method is based on the conversion of radioactive acetyl-CoA to acetyl(−)carnitine in the presence of carnitine acetyltransferase and oxidized glutathione or N -ethylmaleimide to ...
R, Parvin, S V, Pande
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Carnitine, carnitine acyltransferases, and rat brain function
Experimental Neurology, 1982The concentrations of free, short chain, and long chain acylcarnitines and the enzyme activities of carnitine acetyltransferase (CAT) and carnitine palmityltransferase (CPT) were studied in different rat brain regions. The fate of tritium-labeled carnitine was studied in different brain regions in vivo after i.p. injection in 3-month-old Sprague-Dawley
Bresolin N. +3 more
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Neurology, 1980
A 29-year-old women had muscle weakness, low concentrations of carnitine in muscle and serum, and abnormally low urinary excretion of carnitine. During a fast, exercise capacity declined, ketone body concentrations rose, metabolic acidosis worsened, and she became hypoglycemic.
J E, Carroll +6 more
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A 29-year-old women had muscle weakness, low concentrations of carnitine in muscle and serum, and abnormally low urinary excretion of carnitine. During a fast, exercise capacity declined, ketone body concentrations rose, metabolic acidosis worsened, and she became hypoglycemic.
J E, Carroll +6 more
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2004
Nella complessa catena di eventi che conducono all’apoptosi, i mitocondri più che ogni altro organello cellulare assumono ruolo di primaria importanza. L’Autore descrive la rilevanza di fenomeni inducenti un danno mitocondriale e l’eventuale presenza di sostanze che possono influenzarli in qualche modo.
Sara Chelland, Robert Moffatt
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Nella complessa catena di eventi che conducono all’apoptosi, i mitocondri più che ogni altro organello cellulare assumono ruolo di primaria importanza. L’Autore descrive la rilevanza di fenomeni inducenti un danno mitocondriale e l’eventuale presenza di sostanze che possono influenzarli in qualche modo.
Sara Chelland, Robert Moffatt
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Annual Review of Nutrition, 1983
Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and many of the regulatory mechanisms governing carnitine metabolism are ill-defined. Carnitine deficiency can be life threatening but may be resolved with carnitine supplementation.
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Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and many of the regulatory mechanisms governing carnitine metabolism are ill-defined. Carnitine deficiency can be life threatening but may be resolved with carnitine supplementation.
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Metabolic Effects of Carnitine and Carnitine Analogs
1990Cirrhosis of the liver is a common and serious disease with a poor prognosis (1). Loss of liver perfusion and function compromises hepatic detoxification reactions and exposes the central nervous system (CNS) to amino acid imbalances and to multiple toxins including ammonia, mercaptans, short-chain fatty acids, and “middle” molecular weight molecules ...
Y, Ohtsuka, D J, Clark, O W, Griffith
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Pathology, 1985
Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane. Carnitine is metabolized from lysine, trimethyllysine and butyrobetaine. Butyrobetaine undergoes hydroxylation in the liver, brain and kidney to form carnitine which in turn is transported via the plasma to the heart and skeletal muscle
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Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane. Carnitine is metabolized from lysine, trimethyllysine and butyrobetaine. Butyrobetaine undergoes hydroxylation in the liver, brain and kidney to form carnitine which in turn is transported via the plasma to the heart and skeletal muscle
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