Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vector Rhodnius prolixus [PDF]
Frontiers in Physiology, 2023 The energy stored in fatty acids is essential for several critical activities of insects, such as embryogenesis, oviposition, and flight. Rhodnius prolixus is an obligatory hematophagous hemipteran and vector of Chagas disease, and it feeds infrequently ...
Iron F. De Paula +5 more
doaj +2 more sources
Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway [PDF]
Frontiers in Pharmacology, 2020 Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla.
Jiaqi Zhang +6 more
doaj +2 more sources
Une cardiomyopathie révélant un déficit en carnitine palmitoyltransférase I: à propos d´un cas inhabituel [PDF]
The Pan African Medical Journal, 2020 Les déficits en carnitine palmitoyltransférase (CPT) sont des atteintes rares dues à un défaut d´oxydation des acides gras. Patient de 10 ans sans antécédant présenteune dyspnée aigue associée à une toux productive dans un contexte fébrile et d ...
Imane Fetoui +4 more
doaj +2 more sources
Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis [PDF]
International Dental JournalIntroduction and aims: Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. However, the relation between CPT1 and periodontitis is obscure.
Yue Shen +9 more
doaj +2 more sources
Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. [PDF]
PLoS Biology, 2018 It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of ...
Cong-Hui Yao +5 more
doaj +2 more sources
Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice [PDF]
Nutrition & Metabolism, 2019 Background Androgen hormone levels are strongly associated with obesity in adult mammals, especially with advanced age. We investigated androgen receptor inhibition on fat metabolism and long-chain fatty acid (LCFA) transport proteins in skeletal muscle ...
Jisu Kim +4 more
doaj +2 more sources
Inhibition of carnitine palmitoyltransferase I by hepatocyte swelling [PDF]
FEBS Letters, 1994 Incubation of hepatocytes under conditions known to increase their volume, i.e. with amino acids (glutamine, proline) or in hypo‐osmotic medium, decreased carnitine palmitoyl‐transferase I (CPT‐I) activity. This effect of hepatocyte swelling was antagonized by okadaic acid and dibutyryl‐cAMP.
Manuel Guzmán +3 more
openalex +3 more sources
Sertraline-Associated Riboflavin-Responsive Lipid Storage Myopathy: Report of Two Case. [PDF]
Muscle NerveSertraline exposure can lead to an acquired riboflavin‐responsive multiple acyl‐CoA dehydrogenase deficiency (MADD). In patients with this acquired form of MADD, riboflavin supplementation can even lead to full clinical recovery and marked serological recovery before discontinuation of sertraline.
Shaibani A, Taylor A.
europepmc +2 more sources
Hepatic Carnitine Palmitoyltransferase I Deficiency Presenting as Maternal Illness in Pregnancy [PDF]
Pediatric Research, 2000 The spectrum of clinical presentation of fatty acid oxidation defects (FAOD) continues to expand. One FAOD, L-3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency has been associated with liver disease in pregnancies involving a heterozygous mother carrying an affected fetus. Hepatic carnitine palmitoyltransferase (CPT I) deficiency typically presents as
A. Micheil Innes +8 more
openalex +3 more sources
Carnitine palmitoyltransferase I in human carcinomas: A novel role in histone deacetylation? [PDF]
, 2007 Carnitine palmitoyl transferase I (CPT1) catalyzes the transport of long-chain fatty acids into mitochondria for beta-oxidation. A link between CPT1 and apoptosis has been suggested on the basis of several experimental data.
Paola Mazzarelli +5 more
openalex +4 more sources