Results 1 to 10 of about 21,879 (258)

Apigenin Attenuates Acetaminophen-Induced Hepatotoxicity by Activating AMP-Activated Protein Kinase/Carnitine Palmitoyltransferase I Pathway [PDF]

Frontiers in Pharmacology, 2020
Overuse of acetaminophen (APAP) is a major cause of drug-induced liver failure at the clinics. Apigenin (API) is a natural flavonoid derived from Matricaria chamomilla.
Jiaqi Zhang, Xiaoqiang Liang, Jiacheng Li, Hao Yin, Fangchen Liu, Cheng Hu, Ling Li   +6 more
doaj   +4 more sources

Expression of Carnitine Palmitoyltransferase I Isotypes in Gingival Tissues of Human Periodontitis [PDF]

International Dental Journal
Introduction and aims: Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. However, the relation between CPT1 and periodontitis is obscure.
Yue Shen, Lu Lin, Weijun Yu, Zhurong Cui, Tingting Lin, Shucheng Hu, Yuanjie Shi, Yuting Gu, Min Jin, Eryi Lu   +9 more
doaj   +3 more sources

Inhibition of androgen receptor can decrease fat metabolism by decreasing carnitine palmitoyltransferase I levels in skeletal muscles of trained mice [PDF]

Nutrition & Metabolism, 2019
Background Androgen hormone levels are strongly associated with obesity in adult mammals, especially with advanced age. We investigated androgen receptor inhibition on fat metabolism and long-chain fatty acid (LCFA) transport proteins in skeletal muscle ...
Jisu Kim, Jonghoon Park, Nahyun Kim, Hun-young Park, Kiwon Lim   +4 more
doaj   +4 more sources

Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vector Rhodnius prolixus [PDF]

Frontiers in Physiology, 2023
The energy stored in fatty acids is essential for several critical activities of insects, such as embryogenesis, oviposition, and flight. Rhodnius prolixus is an obligatory hematophagous hemipteran and vector of Chagas disease, and it feeds infrequently ...
Iron F. De Paula, Samara Santos-Araujo, David Majerowicz, David Majerowicz, Isabela Ramos, Katia C. Gondim   +5 more
doaj   +2 more sources

Une cardiomyopathie révélant un déficit en carnitine palmitoyltransférase I: à propos d´un cas inhabituel [PDF]

The Pan African Medical Journal, 2020
Les déficits en carnitine palmitoyltransférase (CPT) sont des atteintes rares dues à un défaut d´oxydation des acides gras. Patient de 10 ans sans antécédant présenteune dyspnée aigue associée à une toux productive dans un contexte fébrile et d ...
Imane Fetoui, Karima El Fakiri, Noureddine Rada, Ghizlane Draiss, Mohammed Bouskraoui   +4 more
doaj   +2 more sources

Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. [PDF]

PLoS Biology, 2018
It has been suggested that some cancer cells rely upon fatty acid oxidation (FAO) for energy. Here we show that when FAO was reduced approximately 90% by pharmacological inhibition of carnitine palmitoyltransferase I (CPT1) with low concentrations of ...
Cong-Hui Yao, Gao-Yuan Liu, Rencheng Wang, Sung Ho Moon, Richard W Gross, Gary J Patti   +5 more
doaj   +2 more sources

Altered carnitine-acylcarnitine profiles in levothyroxine-treated congenital hypothyroid patients with fatigue: An LC-MS/MS-based study from Bangladesh. [PDF]

PLoS ONE
Congenital hypothyroidism (CH), characterized by insufficient thyroid hormone production at birth, is frequently associated with fatigue, particularly in cases with delayed diagnosis. This study employed liquid chromatography-tandem mass spectrometry (LC-
Mst Noorjahan Begum, Suprovath Kumar Sarker, Md Tarikul Islam, Golam Sarower Bhuyan, Rumana Mahtarin, Mohammad Hridoy Patwary, Tasnia Kawsar Konika, Syeda Kashfi Qadri, Tasnuva Ahmed, Hurjahan Banu, Nusrat Sultana, Asifuzzaman Rahat, Kohinoor Jahan Shyamaly, Taufiqur Rahman Bhuiyan, Mizanul Hasan, Mohammad A Hasanat, Abu A Sajib, Abul B M M K Islam, Kaiissar Mannoor, Sharif Akhteruzzaman, Firdausi Qadri   +20 more
doaj   +2 more sources

Expression Of Carnitine Palmitoyltransferase I Isotypes In Gingival Tissues

International Dental Journal
Aim or purpose: Carnitine palmitoyltransferase I (CPT1), the rate-limiting enzyme of fatty acid oxidation, plays a crucial role in inflammation. However, the relation between CPT1 and periodontitis is obscure.
Yue Shen, Eryi Lu, Yuting Gu, Min Jin, Zhurong Cui, Tingting Lin, Shucheng Hu, Yuanjie Shi, Lu Lin, Weijun Yu   +9 more
doaj   +2 more sources

Optimal Dietary α-Starch Requirement and Its Effects on Growth and Metabolic Regulation in Chinese Hook Snout Carp (Opsariichthys bidens) [PDF]

Biology
This study investigated the effects of dietary carbohydrate levels on growth performance, body composition, and hepatic expression of metabolic genes in Chinese hook snout carp (Opsariichthys bidens). Fish were fed five isonitrogenous diets with graded α-
Wenjing Cai, Xiaonian Luo, Jiao Li, Youjian Duan, Yong Wei, Yuxin Xing, Zongyun Hu, Chunyue Zhu   +7 more
doaj   +2 more sources

Determination of Metabolomics Profiling in BPA-Induced Impaired Metabolism

Pharmaceutics, 2022
Exposure to bisphenol A (BPA) is unavoidable and it has far-reaching negative effects on living systems. This study aimed to explore the toxic effects of BPA in an experimental animal model through a metabolomics approach that is useful in measuring ...
Maria Alvi, Kanwal Rehman, Muhammad Sajid Hamid Akash, Azka Yaqoob, Syed Muhammad Shoaib   +4 more
doaj   +1 more source