Results 91 to 100 of about 21,999 (257)

CARNITINE PALMITOYLTRANSFERASE II DEFICIENY (CPT II) REFERENCES (MYOPATHY WITH DEFICIENCY OF CARNITINE PALMITOYLTRANSFERASE II; CPT II DEFICIENCY, MYOPATHIC; HYPOGLYCEMIA, HYPOKETOTIC, WITH DEFICIENCY OF CARNITINE PALMITOYLTRANSFERASE II; CPT DEFICIENCY, [PDF]

Mugica M, Rinaldo P.

core  

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi, Xin Liu, Nan Wang, Qianwen Zhang, Jianjun Gao, Canghai Guan, Yapeng Li, Chengru Yang, Shaowu Bi, Xinlei Zou, Xiangyu Zhong   +10 more
wiley   +1 more source

Infection decreases fatty acid oxidation and nuclear hormone receptors in the diaphragm

Journal of Lipid Research, 2009
Respiratory failure is a major cause of mortality during septic shock and is due in part to decreased ventilatory muscle contraction. Ventilatory muscles have high energy demands; fatty acid (FA) oxidation is an important source of ATP.
Kenneth R. Feingold, Arthur Moser, Sophie M. Patzek, Judy K. Shigenaga, Carl Grunfeld   +4 more
doaj   +1 more source

Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: a double-blind placebo-controlled study [PDF]

, 2018
Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility.
Agarwal, A., Antonini, G., Busetto, G. M., De Berardinis, E., Del Giudice, F., Gentile, V., Micic, S., Ragonesi, G., Virmani, A.   +8 more
core   +1 more source

Fetal glucose availability: a key regulator of the metabolic, hormonal and contractility profiles of the fetal sheep heart

The Journal of Physiology, EarlyView.
Abstract figure legend To investigate the role of glucose availability in fetal left ventricle (LV) development, this study assessed whether maternal late gestation undernutrition (LGUN; 50% of Control diet) induced alterations in the contractility, metabolic, and hormonal profile can be ameliorated in LGUN fetuses receiving glucose infusion (LGUN+G ...
Melanie R. Bertossa, Jack R. T. Darby, Stacey L. Holman, Steven K. S. Cho, Ashley S. Meakin, Mitchell C. Lock, Jordan A. Minns, Michael D. Wiese, Christopher K. Macgowan, Mike Seed, Janna L. Morrison   +10 more
wiley   +1 more source

Chirality‐Directed Strategy to Overcome Tumor Resistance to Cuproptosis and Enhance Cuproptosis‐Immunotherapy

Small Structures
Cuproptosis, a recently identified copper‐dependent metabolic cell death pathway, eliminates tumor cell via toxic aggregation of lipoylated enzymes in the tricarboxylic acid cycle.
Hao Zhou, Xiaoyang Zhang, Yu‐Zhang Wang, Shi‐Man Zhang, Hong Chen, Xiao Yan, Chi‐Hui Yang, Wei‐Hai Chen, Xian‐Zheng Zhang   +8 more
doaj   +1 more source

Upregulation of peroxisome proliferator-activated receptor gamma coactivator gene ( PGC1A ) during weight loss is related to insulin sensitivity but not to energy expenditure [PDF]

, 2018
Aims/hypothesis: We investigated whether skeletal muscle peroxisome proliferator-activated receptor gamma coactivator-1 (PGC1A; also known as PPARGC1A) and its target mitofusin-2 (MFN2), as well as carnitine palmitoyltransferase-1 (CPT1; also known as ...
Barthassat, V., Bobbioni-Harsch, E., Gastaldi, G., Giacobino, J.-P, Golay, A., Habicht, F., Muzzin, P., Russell, A.   +7 more
core  

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Effects of Mactra chinenesis Peptides on Alcohol-Induced Acute Liver Injury and Intestinal Flora in Mice

Foods
Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess the novel properties of Mactra chinenesis peptides (MCPs) in mitigating acute alcoholic liver injury in mice ...
Dong Wu, Ming Cheng, Xiangzhou Yi, Guanghua Xia, Zhongyuan Liu, Haohao Shi, Xuanri Shen   +6 more
doaj   +1 more source