Results 121 to 130 of about 21,879 (258)

Time-dependence of inhibition of carnitine palmitoyltransferase I by malonyl-CoA in mitochondria isolated from livers of fed or starved rats. Evidence for transition of the enzyme between states of low and high affinity for malonyl-CoA [PDF]

, 1984
Victor A. Zammit
openalex   +1 more source

Acyl‐CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Aim Acyl‐CoA binding protein plays a vital role in lipid metabolism by mediating the intracellular flux and utilization of long‐chain acyl‐CoAs. We generated an adipocyte‐wide ACBP knockout mouse and a brown adipose tissue‐specific ACBP knockout mouse to investigate ACBP function in adipose tissue.
M. F. Nørremark, R. Petersen, P. M. M. Ruppert, E. S. Jul, T. K. Doktor, R. Nielsen, J. F. Kappel, S. Larsen, J. W. Kornfeld, S. Mandrup, B. S. Andresen, J. Havelund, D. Neess, N. J. Færgeman   +13 more
wiley   +1 more source

Down-regulation of acyl-CoA oxidase gene expression and increased NF-κB activity in etomoxir-induced cardiac hypertrophy

Journal of Lipid Research, 2003
Activation of nuclear factor-κB (NF-κB) is required for hypertrophic growth of cardiomyocytes. Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase I (CPT-I) that activates peroxisome proliferator-activated receptor α (PPARα) and ...
Àgatha Cabrero, Manuel Merlos, Juan C. Laguna, Manuel Vázquez Carrera   +3 more
doaj   +1 more source

Involvement of Ca2+/calmodulin-dependent protein kinase II in the activation of carnitine palmitoyltransferase I by okadaic acid in rat hepatocytes [PDF]

, 1997
Guillermo Velasco, Manuel Guzmán, Victor A. Zammit, Math J.H. Geelen   +3 more
openalex   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

Food Science and Human Wellness
Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble polysaccharide isolated from sweet corncob, an agricultural byproduct.
Xin Wang, Weiye Xiu, Ye Han, Zhili Wang, Yu Luo, Yongqiang Ma   +5 more
doaj   +1 more source

Erigeron annuus (L.) Pers. Extract Inhibits Reactive Oxygen Species (ROS) Production and Fat Accumulation in 3T3-L1 Cells by Activating an AMP-Dependent Kinase Signaling Pathway

Antioxidants, 2019
Obesity is one of the major public health problems in the world because it is implicated in metabolic syndromes, such as type 2 diabetes, hypertension, and cardiovascular diseases. The objective of this study was to investigate whether Erigeron annuus (L.
Yoon-Hee Choi, Ok-Hwan Lee, Yulong Zheng, Il-Jun Kang   +3 more
doaj   +1 more source

Malonyl-CoA-independent Acute Control of Hepatic Carnitine Palmitoyltransferase I Activity [PDF]

, 1998
Guillermo Velasco, Math J.H. Geelen, Teresa Gómez del Pulgar, Manuel Guzmán   +3 more
openalex   +1 more source

Proximal Tubule‐Specific Genetic Deficiency of PPARα Worsens Systemic Lipid and Glucose Metabolism During Fasting

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Proximal tubule‐specific PPARα knockout mouse (PPARαΔKPT) showed decreased lipid and glucose metabolism in the kidney during fasting. Metabolism in the other organs was increased, presumably as a means of compensating for the impaired kidney metabolism.
Daiki Aomura, Takayuki Nimura, Kosuke Yamaka, Yosuke Yamada, Makoto Harada, Takero Nakajima, Takefumi Kimura, Koji Hashimoto, Hiroyuki Kanno, Motoko Yanagita, Frank J. Gonzalez, Naoki Tanaka, Yuji Kamijo   +12 more
wiley   +1 more source

Etomoxir repurposed as a promiscuous fatty acid mimetic chemoproteomic probe

iScience
Summary: Etomoxir has been used for decades as a popular small molecule inhibitor of carnitine palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid β-oxidation. To test the specificity of etomoxir, we generated click chemistry–enabled reagents
Joseph Choi, Danielle M. Smith, Ye Jin Lee, Danfeng Cai, Mohammad J. Hossain, Tamara J. O’Connor, Pragney Deme, Norman J. Haughey, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang   +10 more
doaj   +1 more source