Results 221 to 230 of about 21,879 (258)

Novel therapeutic strategies for targeting fatty acid oxidation in cancer. [PDF]

Biomark Res
Wang Y, Zhang M, Liu J, Li C, Sun N, Wu X, Wang C, Tan X, Yang Y, Qi X, Zhang Y.   +10 more
europepmc   +1 more source

Effect of Ningxiang pig-derived Lactobacillus reuteri supplementation on the growth performance, lipid metabolism, and gut microbiota of finishing pigs. [PDF]

Porcine Health Manag
Xie Q, Yang M, Duanmu Q, Feng L, Liu L, Yin Y, Tan BE, Chen J.   +7 more
europepmc   +1 more source

Pancreatic expression of CPT1A is essential for whole body glucose homeostasis by supporting glucose-stimulated insulin secretion. [PDF]

J Biol Chem
Ducote MP, Cothern CR, Batdorf HM, Fontenot MS, Martin TM, Iftesum M, Gartia MR, Noland RC, Burk DH, Ghosh S, Burke SJ.   +10 more
europepmc   +1 more source

Human Hepatocytes in Experimental Steatosis: Influence of Donor Sex and Sex Hormones. [PDF]

Biomedicines
Seidemann L, Rohm CM, Stilkerich A, Hänsel R, Götz C, Seehofer D, Damm G.   +6 more
europepmc   +1 more source

Tissue-Specific Regulation of Fatty Acid Metabolism in a Mouse Model of Isolated Complex I Deficiency. [PDF]

Proteomics
Khumalo SG, Lindeque JZ, Venter M.
europepmc   +1 more source

Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota

Thümmler K, Basak S, Hulme H, Dritsa C, Foreman R, Naseer H, Salah E, Tumber A, Worboys S, Douce G, Haggarty J, Williams R, Taylor V, Ormsby MJ, Whitfield PD, McCullagh JSO, Salt IP, Burchmore R, Goodwin RJA, Schofield CJ, Wall DM.   +20 more
europepmc   +1 more source

Carnitine palmitoyltransferase I [PDF]

European Journal of Biochemistry, 1983
Palmitate oxidation by liver mitochondria from rats treated with d‐galactosamine (GalN) was markedly inhibited, 3 h after administration. The mitochondrial defect responsible for this inhibition was shown to be an inhibition of the activity of palmitoylcarnitine transferase I (EC 2.3.1.21). Apparent Km of the enzyme remained unchanged whereas apparent
O, Sire, M, Mangeney, J, Montagne, R, Nordmann, J, Nordmann   +4 more
openaire   +3 more sources

(+)-Hemipalmitoylcarnitinium strongly inhibits carnitine palmitoyltransferase-I in intact mitochondria

Journal of Medicinal Chemistry, 1993
The reaction of the methyl ester of (R)-norcarnitine with 1-bromo-2-heptadecanone produces (+)-6-[(methoxycarbonyl)methyl]-2-pentadecyl-4,4-dimethylmorpholinium bromide, 3, which hydrolyzes to (+)-6-(carboxylatomethyl)-2-pentadecyl-4,4-dimethylmorpholinium (hemipalmitoylcarnitinium, HPC) upon treatment with aqueous sodium hydroxide.
R D, Gandour, O T, Leung, A T, Greway, R R, Ramsay, N, Nic a'Bháird, F R, Fronczek, B M, Bellard, G, Kumaravel   +7 more
openaire   +3 more sources

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Deficiency of Carnitine Palmitoyltransferase I

Journal of Child Neurology, 1989
Defective activity of carnitine palmitoyltransferase I was demonstrated in fibroblasts derived from a patient with hypoketotic hypoglycemia. The level of activity observed was approximately 10% of the control mean. Oxidation of palmitate by intact fibroblasts was reduced to 5% of control values. The patient presented at age 14 months with seizures and
J P, Bonnefont, R, Haas, J, Wolff, L P, Thuy, R, Buchta, J E, Carroll, J M, Saudubray, F, Demaugre, W L, Nyhan   +8 more
openaire   +2 more sources

Hyperlipidaemia due to carnitine palmitoyltransferase I deficiency

Journal of Inherited Metabolic Disease, 2006
SummaryWe report a patient with carnitine palmitoyltransferase I (CPT I) deficiency, who presented with acute encephalopathy at 6 months of age. This was precipitated by an episode of gastroenteritis. No hypoglycaemia was documented, but there was hepatomegaly; blood tests revealed raised transaminases, a coagulopathy and severe hypertriglyceridaemia ...
H, Worthington, S E, Olpin, I, Blumenthal, A A M, Morris   +3 more
openaire   +2 more sources