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Direct effect of lipid emulsion treatment on local anesthetic systemic toxicity. [PDF]
Sohn JT.
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Predictive Role of Metabolic Profiling in Rivaroxaban Efficacy for Thrombus Lysis in Atrial Fibrillation. [PDF]
Michorowska S +4 more
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How the Renal Tubule May Adapt to Fuel Shortage. [PDF]
Miguel V, Lamas S.
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Inhibition of systemic mammalian metabolism by carnitine mimics from the gut microbiota
Thümmler K +20 more
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Deficiency of Carnitine Palmitoyltransferase I
Journal of Child Neurology, 1989Defective activity of carnitine palmitoyltransferase I was demonstrated in fibroblasts derived from a patient with hypoketotic hypoglycemia. The level of activity observed was approximately 10% of the control mean. Oxidation of palmitate by intact fibroblasts was reduced to 5% of control values. The patient presented at age 14 months with seizures and
J P, Bonnefont +8 more
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Hyperlipidaemia due to carnitine palmitoyltransferase I deficiency
Journal of Inherited Metabolic Disease, 2006SummaryWe report a patient with carnitine palmitoyltransferase I (CPT I) deficiency, who presented with acute encephalopathy at 6 months of age. This was precipitated by an episode of gastroenteritis. No hypoglycaemia was documented, but there was hepatomegaly; blood tests revealed raised transaminases, a coagulopathy and severe hypertriglyceridaemia ...
H, Worthington +3 more
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Carnitine palmitoyltransferase I
European Journal of Biochemistry, 1983Palmitate oxidation by liver mitochondria from rats treated with d‐galactosamine (GalN) was markedly inhibited, 3 h after administration. The mitochondrial defect responsible for this inhibition was shown to be an inhibition of the activity of palmitoylcarnitine transferase I (EC 2.3.1.21). Apparent Km of the enzyme remained unchanged whereas apparent
O, Sire +4 more
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Features of carnitine palmitoyltransferase type I deficiency
Journal of Inherited Metabolic Disease, 2001AbstractCarnitine palmitoyltransferase type I (CPT I) is unique among long‐chain fatty acid oxidation enzymes in that there are two tissue‐specific isoforms, ‘hepatic’ and ‘muscle’, which are encoded by two separate genes. The ‘hepatic’ isoform is expressed in liver, kidney and fibroblasts and at low levels in the heart, while the other isoform occurs ...
S E, Olpin +12 more
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