Results 21 to 30 of about 21,999 (257)

A Requirement for Fatty Acid Oxidation in the Hormone-Induced Meiotic Maturation of Mouse Oocytes [PDF]

, 2013
We have previously shown that fatty acid oxidation (FAO) is required for AMP-activated protein kinase (PRKA)-induced maturation in vitro. In the present study, we have further investigated the role of this metabolic pathway in hormone-induced meiotic ...
Downs, Stephen, Valsangkar, Deepa
core   +2 more sources

Carnitine Inborn Errors of Metabolism

Molecules, 2019
Carnitine plays essential roles in intermediary metabolism. In non-vegetarians, most of carnitine sources (~75%) are obtained from diet whereas endogenous synthesis accounts for around 25%.
Mohammed Almannai, Majid Alfadhel, Ayman W. El-Hattab   +2 more
doaj   +1 more source

Differences in Breast Muscle Mitochondrial Respiratory Capacity, Reactive Oxygen Species Generation, and Complex Characteristics between 7-week-old Meat- and Laying-type Chickens

The Journal of Poultry Science, 2020
The skeletal muscle growth rate is a major feature differentiating meat- and laying-type chickens. A large amount of ATP is required during skeletal muscle synthesis, in which mitochondrial energy production capacities play a significant role ...
Yuki Hakamata, Masaaki Toyomizu, Motoi Kikusato   +2 more
doaj   +1 more source

Fatty Acid Oxidation and Meiotic Resumption in Mouse Oocytes [PDF]

, 2009
We have examined the potential role of fatty acid oxidation (FAO) in AMP-activated protein kinase (AMPK)-induced meiotic maturation. Etomoxir and malonyl CoA, two inhibitors of carnitine palmitoyl transferase-1 (CPT1), and thus FAO, blocked meiotic ...
Downs, Stephen, Klinger, John, Odette, Jessica   +2 more
core   +2 more sources

Muscle Carnitine Palmitoyltransferase II (CPT II) Deficiency: A Conceptual Approach

Molecules, 2020
Carnitine palmitoyltransferase (CPT) catalyzes the transfer of long- and medium-chain fatty acids from cytoplasm into mitochondria, where oxidation of fatty acids takes place.
Pushpa Raj Joshi, Stephan Zierz
doaj   +1 more source

Molecular basis of hepatic carnitine palmitoyltransferase I deficiency. [PDF]

Journal of Clinical Investigation, 1998
Mitochondrial fatty acid beta-oxidation is important for energy production, which is stressed by the different defects found in this pathway. Most of the enzyme deficiencies causing these defects are well characterized at both the protein and genomic levels.
IJlst, H., Mandel, J.L., Oostheim, W., Ruiter, J.P.N., Gutman, A., Wanders, R.J.A.   +5 more
openaire   +4 more sources

CYC31, A Natural Bromophenol PTP1B Inhibitor, Activates Insulin Signaling and Improves Long Chain-Fatty Acid Oxidation in C2C12 Myotubes

Marine Drugs, 2020
3-bromo-4,5-Bis(2,3-dibromo-4,5-dihydroxybenzyl)-1,2-benzenediol (CYC31) is a bromophenol protein tyrosine phosphatase 1B (PTP1B) inhibitor isolated from the red alga Rhodomela confervoides.
Jiao Luo, Yufei Hou, Mengyue Xie, Wanli Ma, Dayong Shi, Bo Jiang   +5 more
doaj   +1 more source

Antidiabetic agents: a new class of reversible carnitine palmitoyltransferase I inhibitors

Journal of Medicinal Chemistry, 1995
Robert C. Anderson, Michael Balestra, Philip Bell, Rhonda Oetting Deems, William S. Fillers, James E. Foley, James D. Fraser, W. Mann, Markus Rudin, Edwin B. Villhauer   +9 more
openalex   +3 more sources

Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs [PDF]

, 2012
BACKGROUND: Fibroblast growth factor 21 (FGF21), whose expression is induced by peroxisome proliferator-activated receptor alpha (PPARalpha), has been recently identified as a novel metabolic regulator which plays a crucial role in glucose homeostasis ...
Eder, Klaus, Ringseis, Robert, Varady, Juliane   +2 more
core   +2 more sources

Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation

Journal of Lipid Research, 1999
3-Thia fatty acids are modified fatty acids that promote hepatic peroxisome proliferation and decrease serum triacylglycerol, cholesterol and free fatty acid levels in rats.
E. Raspé, L. Madsen, A-M. Lefebvre, I. Leitersdorf, L. Gelman, J. Peinado-Onsurbe, J. Dallongeville, J-C. Fruchart, R. Berge, B. Staels   +9 more
doaj   +1 more source