Results 61 to 70 of about 21,999 (257)

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, EarlyView.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Direct Expression of CPT1a Enables a High Throughput Platform for the Discovery of CPT1a Modulators

Applied Biosciences
Carnitine palmitoyltransferase 1 (CPT1), which catalyzes the rate-limiting step of fatty acid oxidation, has been implicated in therapeutic approaches to several human diseases characterized by aberrant lipid metabolism.
Jason Chen, Tuyen Tran, Anthony Wong, Luofei Wang, Pranavi Annaluru, Vibha Sreekanth, Samika Murthy, Laasya Munjeti, Tanya Park, Utkarsh Bhat, Glynnis Leong, Yumeng Li, Simeng Chen, Natalie Kong, Rushika Raval, Yining Xie, Shreya Somani, Aditi Manohar Bhambhani, Zoey Zhu, Landen Chu, Kimai Dosch, Edward Njoo, Zhan Chen   +22 more
doaj   +1 more source

Recurrent rhabdomyolysis caused by carnitine palmitoyltransferase II deficiency, common but under-recognised: Lessons to be learnt [PDF]

, 2018
We discuss two adult siblings who presented with symptoms of myalgia and rhabdomyolysis following exercise with myoglobinuria; genetic testing confirmed carnitine palmitoyltransferase II deficiency and resulted in institution of appropriate crisis ...
Balasubramanian, M., Gillett, G.T., Hill, M., Jenkins, T.M., Kirk, R.J., Nesbitt, I.M., Olpin, S.E.   +6 more
core   +2 more sources

Immunoquantitative Analysis of Human Carnitine Palmitoyltransferase I and II Defects [PDF]

Pediatric Research, 1990
Carnitine palmitoyltransferase deficiency realizes two distinct clinical forms. We previously showed and confirmed in the present work that CPTII (identified as the carnitine palmitoyltransferase activity assayable in detergent conditions) is decreased in the muscular form whereas it is unaffected and CPTI is decreased in the hepatic form. The antibody
F, Demaugre, J P, Bonnefont, C, Cepanec, J, Scholte, J M, Saudubray, J P, Leroux   +5 more
openaire   +2 more sources

Carnitine palmitoyltransferase IA polymorphism P479L is common in Greenland Inuit and is associated with elevated plasma apolipoprotein A-I

Journal of Lipid Research, 2009
Carnitine palmitoyltransferase IA, encoded by CPT1A, is a key regulator of fatty acid metabolism. Previously, a loss-of-function mutation, namely, c.1436 C→T (p.P479L), was reported in CPT1A in the homozygous state in Canadian aboriginal male with ...
Chandheeb Rajakumar, Matthew R. Ban, Henian Cao, T. Kue Young, Peter Bjerregaard, Robert A. Hegele   +5 more
doaj   +1 more source

Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals [PDF]

, 2015
Background: The enzyme fatty acid synthase (FASN) is highly expressed in many human carcinomas and its inhibition is cytotoxic to human cancer cells. The use of FASN inhibitors has been limited until now by anorexia and weight loss, which is associated ...
Brunet, Joan, Colomer Bosch, Ramón, Haro Bautista, Diego, Marrero González, Pedro F., Puig i Miquel, Teresa, Relat Pardo, Joana   +5 more
core  

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Effets de l’acide trans-10, cis-12 linoléique sur le métabolisme des lipides dans le foie chez la souris C57BL/6

Oléagineux, Corps gras, Lipides, 2005
A 4-week diet containing 1% of the conjugated trans-10,cis-12 linoleic acid (CLA2) induces, in C57BL/6 mice, a lipodystrophy, a liver steatosis and a reduction of plasma triglycerides.
Degrace Pascal, Demizieux Laurent, Mohamed Ismaël, Gresti Joseph, Chardigny Jean-Michel, Sébédio Jean-Louis, Clouet Pierre   +6 more
doaj   +1 more source

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss [PDF]

, 2016
Excessive accumulation of fat as the result of more energy intake and less energy expenditure is known as obesity. Lipids are essential components in the human body and are vital for maintaining homeostasis and physiological as well as cellular ...
Mantso, Theodora, Panagiotidis, Mihalis, Rupasinghe, Vasantha, Sekhhon-Loodu, Satvir   +3 more
core   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source