Results 71 to 80 of about 21,879 (258)

Hepatic Carnitine Palmitoyltransferase I Deficiency Presenting as Maternal Illness in Pregnancy [PDF]

Pediatric Research, 2000
The spectrum of clinical presentation of fatty acid oxidation defects (FAOD) continues to expand. One FAOD, L-3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency has been associated with liver disease in pregnancies involving a heterozygous mother carrying an affected fetus. Hepatic carnitine palmitoyltransferase (CPT I) deficiency typically presents as
Innes, A. M., Seargeant, L. E., Balachandra, K., Roe, C. R., Wanders, R. J., Ruiter, J. P., Casiro, O., Grewar, D. A., Greenberg, C. R.   +8 more
openaire   +2 more sources

Open-label clinical trial of bezafibrate treatment in patients with fatty acid oxidation disorders in Japan [PDF]

, 2018
IntroductionFatty acid oxidation disorders (FAODs) are rare diseases caused by defects in mitochondrial fatty acid oxidation (FAO) enzymes. While the efficacy of bezafibrate, a peroxisome proliferator-activated receptor agonist, on the in vitro FAO ...
Asahina Naoko, Fukao Toshiyuki, Hamada Yusuke, Hayashi Hiroshi, Ishige Mika, Isoe Toshiyuki, Kawakami Sanae, Kuzume Kazuyo, Miyakoshi Takashi, Nakamagoe Kiyotaka, Oba Koji, Ochi Fumihiro, Oki Eishin, Ono Kota, Sakai Norio, Sameshima Koji, Sato Norihiro, Shiraishi Hideaki, Tamaoka Akira, Watanabe Asami, Watanabe Kenji, Yamada Kenji, Yamaguchi Seiji, Yokoshiki Saki, 中馬越 清隆, 玉岡 晃   +25 more
core   +2 more sources

Lactobacillus plantarum CQPC02 Prevents Obesity in Mice through the PPAR-α Signaling Pathway

Biomolecules, 2019
We determined the lipid-lowering effect of a new strain of the lactic acid bacteria Lactobacillus plantarum CQPC02 (LP-CQPC02), from Sichuan pickled cabbages, using an in vivo animal model. A high-fat diet was used to generate obese mice.
Xin Zhao, Jing Zhang, Sha Yi, Xixi Li, Zemei Guo, Xianrong Zhou, Jianfei Mu, Ruokun Yi   +7 more
doaj   +1 more source

Rate-Dependent Distal Renal Tubular Acidosis and Carnitine Palmitoyltransferase I Deficiency [PDF]

Pediatric Research, 1994
An infant girl presented with recurrent episodes of Reye-like syndrome associated with hypoketosis and plasma carnitine levels in the high-normal range. A liver biopsy revealed massive macrovesicular steatosis. Ketogenesis was absent after a long-chain triglyceride loading test; in contrast, the medium-chain triglyceride loading test resulted in a ...
Bergman, A. J., Donckerwolcke, R. A., Duran, M., Smeitink, J. A., Mousson, B., Vianey-Saban, C., Poll-The, B. T.   +6 more
openaire   +3 more sources

Cardiac metabolism — A promising therapeutic target for heart failure [PDF]

, 2017
Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality.
Frenneaux, Michael P, Loudon, Brodie L, Madhani, Melanie, Noordali, Hannah   +3 more
core   +2 more sources

Green tea catechin inhibits fatty acid synthase without stimulating carnitine Palmitoyltransferase-1 or inducing weight loss in experimental animals [PDF]

, 2015
Background: The enzyme fatty acid synthase (FASN) is highly expressed in many human carcinomas and its inhibition is cytotoxic to human cancer cells. The use of FASN inhibitors has been limited until now by anorexia and weight loss, which is associated ...
Brunet, Joan, Colomer Bosch, Ramón, Haro Bautista, Diego, Marrero González, Pedro F., Puig i Miquel, Teresa, Relat Pardo, Joana   +5 more
core  

The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice [PDF]

, 2003
Adiponectin has recently been shown to be a promising candidate for the treatment of obesity-associated metabolic syndromes. Replenishment of recombinant adiponectin in mice can decrease hyperglycemia, reverse insulin resistance, and cause sustained ...
Adachi, Baraona, Bijleveld, Campfield, Combs, Diehl, Funabiki, Guzman, Hill, Hotta, Kubota, Kudo, Lindros, McClain, Molina, Ouchi, Ouchi, Piot, Siler, Wilkes, Winder, Yokota   +21 more
core   +2 more sources

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Cells, 2019
Lipid droplets (LDs) serve as energy rich reservoirs and have been associated with apolipoprotein E (APOE) and neurodegeneration. The E4 allele of APOE (E4) is the strongest genetic risk factor for the development of late onset Alzheimer’s disease (
Brandon C. Farmer, Jude Kluemper, Lance A. Johnson   +2 more
doaj   +1 more source

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation [PDF]

, 2015
Lipid overload in obesity and type 2 diabetes is associated with adipocyte dysfunction, inflammation, macrophage infiltration, and decreased fatty acid oxidation (FAO). Here, we report that the expression of carnitine palmitoyltransferase 1A (CPT1A), the
Belén Peral, Dolors Serra, Francesc Villarroya, Joan Francesc Mir, Joan J Vendrell, Laia Salvadó, Laura Herrero, Lorea Valcarcel, Manuel Vázquez-Carrera, Maria Ida Malandrino, María Calderon-Dominguez, María Gómez-Serrano, Minéia Weber, Núria Casals, Raquel Fucho, Sonia Fernández-Veledo, Xavier Escoté   +16 more
core   +2 more sources