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Carnosine and Carnosine-Related Antioxidants: A Review
Current Medicinal Chemistry, 2005First isolated and characterized in 1900 by Gulewitsch, carnosine ( β-alanyl-L-hystidine) is a dipeptide commonly present in mammalian tissue, and in particular in skeletal muscle cells; it is responsible for a variety of activities related to the detoxification of the body from free radical species and the by-products of membrane lipids ...
Andrea Guiotto +3 more
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Rejuvenation Research, 2022
Diabetic encephalopathy (DE) is one of complications of diabetes mellitus. Carnosine is a dipeptide composed of β-alanine and l-histidine. Study has shown that carnosine could ameliorate cognitive impairment in animal model with diabetes mellitus ...
Dong Peng +8 more
semanticscholar +1 more source
Diabetic encephalopathy (DE) is one of complications of diabetes mellitus. Carnosine is a dipeptide composed of β-alanine and l-histidine. Study has shown that carnosine could ameliorate cognitive impairment in animal model with diabetes mellitus ...
Dong Peng +8 more
semanticscholar +1 more source
Carnosine and Diabetic Nephropathy
Current Medicinal Chemistry, 2020Diabetic Nephropathy (DN) is a major complication in patients with type 1 or type 2 diabetes and represents the leading cause of end-stage renal disease. Novel therapeutic approaches are warranted. In view of a polymorphism in the carnosinase 1 gene CNDP1, resulting in reduced carnosine degradation activity and a significant DN risk reduction ...
Verena, Peters +2 more
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Current Medicinal Chemistry, 2020
Carnosine (β-alanyl-L-histidine) is a small dipeptide with numerous activities, including antioxidant effects, metal ion chelation, proton buffering capacity, and inhibitory effects on protein carbonylation and glycation. Carnosine has been mostly studied in organs where it is abundant, including skeletal muscle, cerebral cortex, kidney, spleen, and ...
Ken-Ichiro, Tanaka, Masahiro, Kawahara
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Carnosine (β-alanyl-L-histidine) is a small dipeptide with numerous activities, including antioxidant effects, metal ion chelation, proton buffering capacity, and inhibitory effects on protein carbonylation and glycation. Carnosine has been mostly studied in organs where it is abundant, including skeletal muscle, cerebral cortex, kidney, spleen, and ...
Ken-Ichiro, Tanaka, Masahiro, Kawahara
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Carnosine and the processes of ageing
Maturitas, 2016The causes of ageing are usually regarded as multifactorial; thus effective regulation might be achieved by intervention at multiple sites. It has been suggested that the endogenous dipeptide carnosine, also available as a food supplement, possesses anti-ageing activity and may achieve its reported age-alleviating effects via a number of mechanisms ...
Alan R, Hipkiss +2 more
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Carnosine in Nucleated Erythrocytes
Nature, 1974IN the course of studies of the metabolism of intracerebrally administered L-U-14C-histidine in brains of mice and frogs (Rana pipiens), analyses were also performed on blood samples from the injected animals. The mice received 1.5×106 c.p.m. of the labelled histidine, and 1 h later samples of blood were taken by means of orbital puncture.
J N, Van Balgooy +2 more
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Free radical research, 2020
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent several oxidative based diseases including lung disease, type 2 diabetes and its micro and macrovascular complications, cardiovascular disorders, neurodegenerative ...
G. Aldini +9 more
semanticscholar +1 more source
Carnosine is an endogenous dipeptide whose oral administration has been found to prevent several oxidative based diseases including lung disease, type 2 diabetes and its micro and macrovascular complications, cardiovascular disorders, neurodegenerative ...
G. Aldini +9 more
semanticscholar +1 more source
Experientia, 1981
Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Carnosine levels were determined in chick erythrocytes (2510 nmoles/g cells) and plasma from chick (27 nmoles/ml),rat and rabbit. Carnosine was also measured in rabbit reticulocyte-rich blood (105 nmoles/g cells), normal blood (18 nmoles/g cells) and in bone marrow.
J E, Seely, F D, Marshall
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Antioxidant activities of carnosine, anserine, some free amino acids and their combination
, 2020For the evaluation of antioxidant activities of dipeptides (carnosine, anserine), and free amino acids (histidine, 1-methylhist idine, taurine, glycine, alanine, β-alanine), four methods were used, including the analysis of the inhibition of linoleic ...
Hui-Chun Wu +3 more
semanticscholar +1 more source
Brain Research, 1979
The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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The dipeptide, carnosine, its synthetic enzyme, carnosine synthetase, and its degradative enzyme, carnosinase, appear to be localized in the cytosol of mouse olfactory bulb and epithelium. Mouse olfactory bulbs and epithelium were prelabeled in vivo with [3H]carnosine following intranasal irrigation with [3H]beta-alanine.
J W, Harding, J V, O'Fallon
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