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Therapeutic potential of carnosine and its derivatives in the treatment of human diseases.
Chemical Research in Toxicology, 2020Despite significant progress in the pathogenesis, diagnosis, treatment and prevention of cancer and neu-rodegenerative diseases, their occurence and mortality is still high around the world.
Klaudia Chmielewska +3 more
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Physiologic Properties of Anserine and Carnosine
American Journal of Physiology-Legacy Content, 1956Studies were made of physiologic responses to anserine and carnosine, isolated and synthetic, as measured by changes in diastolic, pulse and systolic blood pressure and peripheral blood flow in the cat and dog, and by oxytocic effects on smooth muscle of guinea pig and rabbit.
H M, HINES, D C, SUTFIN
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Protective effect of carnosine in hyperthermia
Bulletin of Experimental Biology and Medicine, 1997Under the conditions of hyperthermia, carnosine (β-alanine-l-histidine) normalizes tissue contents of lipid peroxidation products, cytochrome P-450, serotonin, and histamine in rats and increases their survival after extreme hyperthermia.
L I, Deev +5 more
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Carnosine reacts with a glycated protein
Free Radical Biology and Medicine, 2000Oxidation and glycation induce formation of carbonyl (CO) groups in proteins, a characteristic of cellular aging. The dipeptide carnosine (beta-alanyl-L-histidine) is often found in long-lived mammalian tissues at relatively high concentrations (up to 20 mM).
C, Brownson, A R, Hipkiss
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Neurochemical Research, 1977
The amount and specificity of binding ofL-carnosine (β-alanyl-L-histidine) by crude soluble and particulate fractions of several tissues were investigated with proton magnetic resonance ((1)HMR) spectrometry. It was found that the particulate fraction of only nasal olfactory mucosa exhibited a specific binding requiring a particular orientation of the ...
C E, Brown +4 more
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The amount and specificity of binding ofL-carnosine (β-alanyl-L-histidine) by crude soluble and particulate fractions of several tissues were investigated with proton magnetic resonance ((1)HMR) spectrometry. It was found that the particulate fraction of only nasal olfactory mucosa exhibited a specific binding requiring a particular orientation of the ...
C E, Brown +4 more
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Carnosine and Carnosinase in Rat Tissue
Nature, 1957PAPER chromatography has been used for obtaining a qualitative picture of the distribution of carnosine and ‘carnosinase’ in the albino rat.
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Carnosine, carnitine, and Vladimir Gulevich
Journal of Chemical Education, 1974Vladimir Gulevich was a distinguished biochemist who was responsible for the discovery of several biologically important bases and who inspired some extremely capable students and associated to con...
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Carnosine in the Primary Olfactory Pathway
Science, 1974Carnosine (β-alanyl-L-histidine) is present in mouse olfactory bulbs and nasal olfactory epithelium at concentrations exceeding that previously reported for any brain region of any species. After peripheral deafferentation, carnosine concentrations in the olfactory bulbs decrease to less than 10 percent that of normal, while other amino compounds are ...
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