Results 121 to 130 of about 1,483,650 (393)

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

open access: yesAdvanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia   +13 more
wiley   +1 more source

The roles of endoglin gene in cerebrovascular diseases. [PDF]

open access: yes, 2017
Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis.
Ma, Li, Su, Hua, Zhang, Rui, Zhu, Wan
core   +2 more sources

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

open access: yesAdvanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong   +22 more
wiley   +1 more source

THE “EXTRA-MEDIA” THICKNESS OF CAROTID ARTERIES AS A NOVEL MARKER OF PERIVASCULAR VISCERAL ADIPOUS TISSUE: ACCENT ON THE RELATION WITH VASCULAR REMODELLING PARAMETERS

open access: yesРоссийский кардиологический журнал, 2016
Aim. To perform ultrasound assessment of the “extra-media” thickness (EMT) of carotid arteries and to analyze its association with vascular stiffness and sonographical indexes of carotid arteries condition in patients with abdominal obesity.Material and ...
M. A. Druzhilov   +3 more
doaj   +1 more source

Early tumor response to intraarterial or intravenous administration of carboplatin to treat naturally occurring lower urinary tract carcinoma in dogs. [PDF]

open access: yes, 2015
BackgroundSurvival times and tumor responses associated with malignant neoplasia of the lower urinary tract are poor despite the vast array of current treatments.
Berent, AC   +8 more
core  

Intima-Media Thickness in the Carotid and Femoral Arteries for Detection of Arteriosclerosis in Human Immunodeficiency Virus-Positive Individuals [PDF]

open access: diamond, 2016
Emmanuelle Tenório Albuquerque Madruga Godoi   +9 more
openalex   +1 more source

Carotid artery stenting

open access: yesCurrent Opinion in Cardiology, 2019
To present the latest evidence about carotid artery stenting (CAS) including indications, safety, efficacy, and available equipment.The micromesh stent, a new stent design which offers excellent flexibility and embolic protection, has been associated with promising outcomes.CAS has emerged as a minimally invasive treatment method for carotid artery ...
Spiliopoulos, S.   +4 more
openaire   +3 more sources

Cortical Microvascular Pulsatility in the Aging Mouse Brain and the Confounding Effects of Anesthesia

open access: yesAdvanced Science, EarlyView.
Multi‐modal optical imaging reveals microvascular pulsatility in the brain cortex of awake and anaesthetized mice. Awake hemodynamics in male mice are found to be remarkably stable until late life, with flow pulsatility being significantly higher than in females, despite similar average perfusion.
Mia Viuf Skøtt   +5 more
wiley   +1 more source

“Time Is Brain” – for Cell Therapies

open access: yesAdvanced Science, EarlyView.
The concept that “time is brain” extends to stem cell therapy for stroke. Evidence across preclinical and clinical studies indicates that delivery timing shapes graft survival, integration, and efficacy by matching the evolving post‐stroke microenvironment.
Hao Yin   +4 more
wiley   +1 more source

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