Results 41 to 50 of about 118,057 (267)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Histological evaluation of the common carotid arteries in the goat (Capra Hircus)

Cluj Veterinary Journal
Fragments of the common carotid arteries were collected from 8 goats that had succumbed to accidents. These samples underwent histological processing, involving fixation and embedding in paraffin.
Cosmin Cret, Mircea Cipou , Bogdan Cătălin Alexandru, Alexandra Irimie, Aurel Damian   +4 more
doaj   +1 more source

Separate origins of the left internal and external carotid arteries from the aorta in a patient with intracerebral hemorrhage

Radiology Case Reports, 2022
Agenesis of the left common carotid artery with separate origins of the left internal and external carotid arteries from the aorta is an extremely rare anomaly. This anomaly is typically asymptomatic unless associated with other conditions.
Yuma Hiratsuka, MD, Hideki Endo, MD, PhD, Naoyasu Okamura, MD, Masaaki Mikamoto, MD, Bunsho Asayama, MD, Kenji Kamiyama, MD, Toshiaki Osato, MD, Hirohiko Nakamura, MD, PhD   +7 more
doaj   +1 more source

Systemic Extracerebral Atherosclerotic Burden and Dementia Risk After Incident Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stroke survivors are at increased risk of dementia, but clinically accessible markers of risk heterogeneity remain limited. Previous studies have largely examined atherosclerotic disease in individual vascular beds rather than the overall burden of systemic extracerebral atherosclerosis.
Zhexuan Yu, Tianxue Chen, Wei Jin, Weifeng Jin, Haitong Wan   +4 more
wiley   +1 more source

Diagnostic Accuracy of Duplex Ultrasonography Versus Computed Tomographic Angiography in the Detection of Significant Carotid Artery Atherosclerosis

Pakistan Armed Forces Medical Journal
Objective: To determine the diagnostic accuracy Duplex of Ultrasonography in detecting clinically significant carotid atherosclerosis by keeping Computed Tomographic Angiography as a gold standard.
Iram Aziz, Muhammad Nafees, Iram Mohsin, Shabana .   +3 more
doaj   +1 more source

Microvascular Damage Is Associated With Carotid Wall Structural Changes in Systemic Sclerosis: A Capillaroscopy and Ultrasound‐Based Observational Study

Arthritis Care &Research, EarlyView.
Objective Systemic sclerosis (SSc) is characterized by cardiovascular risk excess not fully explained by traditional factors. Whether the severity of microvascular damage correlates with structural subclinical atherosclerosis remains unclear. We investigated the relationship between nailfold videocapillaroscopy (NVC) abnormalities and carotid ...
Eugenio Capparelli, Luca Clerici, Francesco Lapia, Giusy C. Moltisanti, Eleonora Zaccara, Greta Pellegrino, Daniela Bompane, Francesca Capelli, Letizia Ferrami, Laura Castelnovo, Antonio Tamburello, Maria Sole Chimenti, Paola Faggioli, Antonino Mazzone   +13 more
wiley   +1 more source

Ultrasound Carotid Plaque Score and Severity of Coronary Artery Disease Assessed by Computed Tomography Angiography in Patients with Arterial Hypertension

Diagnostics
The aim of the study was to assess the relationship between the presence of atherosclerotic lesions in the carotid arteries detected by ultrasound and the occurrence of atherosclerosis in the coronary arteries determined by computed tomography (CT) in ...
Andrzej Wysocki, Michał Fułek, Piotr Macek, Monika Michałek-Zrąbkowska, Krzysztof Kraik, Małgorzata Poręba, Katarzyna Fułek, Helena Martynowicz, Grzegorz Mazur, Paweł Gać, Rafał Poręba   +10 more
doaj   +1 more source

Prevalence and Characteristics of Carotid Artery High‐Risk Atherosclerotic Plaques in Chinese Patients With Cerebrovascular Symptoms: A Chinese Atherosclerosis Risk Evaluation II Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundCarotid atherosclerotic plaque rupture is an important source of ischemic stroke. However, the prevalence of high‐risk plaque (HRP) defined as plaques with luminal surface disruption, a lipid‐rich necrotic core occupying >40% of the wall, or ...
Xihai Zhao, Daniel S. Hippe, Rui Li, Gador M. Canton, Binbin Sui, Yan Song, Feiyu Li, Yunjing Xue, Jie Sun, Kiyofumi Yamada, Thomas S. Hatsukami, Dongxiang Xu, Maoxue Wang, Chun Yuan   +13 more
doaj   +1 more source

Carotid artery stenting [PDF]

Heart, 2003
Two major randomised trials concerning the surgical treatment of carotid artery stenosis showed that carotid endarterectomy is superior to medical treatment in reducing the overall risk of stroke in symptomatic or asymptomatic patients.w1–4 The first phase of the North American endarterectomy trial (NASCET)w1 confirmed the superiority for symptomatic ...
Francesco, Liistro, Carlo, Di Mario
openaire   +2 more sources

Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis

Arthritis Care &Research, Accepted Article.
OBJECTIVE Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health outcomes after elective non‐cardiac surgery. METHODS We conducted a cross‐sectional study using the National Inpatient Sample (2018 to 2020), including ...
Ali Yazdanyar, Joshua Baker, Katherine D Wysham, Mohammed Yousufuddin, Farah Acher Kaiksow, Michael M. Ward   +5 more
wiley   +1 more source