Results 91 to 100 of about 265,246 (347)

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science, EarlyView.
This study reveals that the glycolytic enzyme HK2 mediates hypoxia‐induced astrocytic exosome biogenesis by directly phosphorylating nSMase1. These astrocytic exosomes impair brain endothelial tight junctions. Astrocyte‐specific knockdown of HK2 reduces exosome release and alleviates brain injury after MCAO.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
wiley   +1 more source

Early tumor response to intraarterial or intravenous administration of carboplatin to treat naturally occurring lower urinary tract carcinoma in dogs. [PDF]

, 2015
BackgroundSurvival times and tumor responses associated with malignant neoplasia of the lower urinary tract are poor despite the vast array of current treatments.
Berent, AC, Clifford, CA, Culp, WTN, Jackson, DE, Kass, PH, Krick, EL, Reetz, JA, Sorenmo, KU, Weisse, C   +8 more
core  

The acute effect of maximal exercise on central and peripheral arterial stiffness indices and hemodynamics in children and adults [PDF]

, 2016
Xavier Melo is supported by a research grant from the Foundation for Science and Technology (FCT), Ministry of Education and Science of Portugal (grant: SFRH/ BD/ 70515/ 2010). Nuno M.
Fernhall, Bo, Melo, Xavier, Pimenta, Nuno, Pinto, Rita, Santa-Clara, Helena, Santos, Diana, Sardinha, Luis   +6 more
core   +1 more source

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, EarlyView.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Management of Noncatastrophic Internal Carotid Artery Injury in Endoscopic Skull Base Surgery. [PDF]

, 2019
Arterial injuries are the most feared complication of endoscopic skull base surgery. During resection of the middle fossa component of a large ventral skull base chondrosarcoma, arterial bleeding was encountered near the right internal carotid artery ...
El-Sayed, Ivan H, Safaee, Michael, Theodosopoulos, Philip V, Young, Jacob S   +3 more
core  

Responses to stimulation of coronary and carotid baroreceptors and the coronary chemoreflex at different ventricular distending pressures in anaesthetised dogs [PDF]

, 2001
Stimulation of left ventricular mechanoreceptors was believed not only to exert important effects on the circulation, but also to influence the responses to baroreceptor reflexes.
Drinkhill, M.J., Hainsworth, R., Wright, C.I.   +2 more
core   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Ophthalmic artery originating from contralateral internal carotid artery associated with ipsilateral agenesis of internal carotid artery

Radiology Case Reports
Congenital absence of the internal carotid artery is a rare anatomical variant. The primarily reported origins of the ophthalmic artery associated with this variant are the posterior communicating, middle cerebral, and external carotid arteries.
Takaki Hamada, Daisuke Itoh, Wataro Tsuruta, Satoshi Nakamura, Tomohiko Masumoto   +4 more
doaj   +1 more source

Ruptured Aneurysm of Extracranial Carotid Artery

Journal of Nepal Medical Association, 2008
Aneurysm of extracranial carotid artery is an uncommon clinical disease and that presenting as a ruptured aneurysm is extremely rare. This entity represents a challenge to treatment strategy.
Uttam Krishna Shrestha
doaj   +1 more source