Results 231 to 240 of about 99,873 (264)

Ageing reveals the latent effects of early life stress on respiratory and metabolic function in female rats: Novel insights into the sex‐specific origins of sleep apnoea

open access: yesExperimental Physiology, EarlyView.
Abstract Sleep apnoea (SA) is ∼2 times more prevalent in men than women. However, this changes at menopause as the occurrence of SA increases and matches that of men. Menopause is a natural process, but it remains unclear why SA emerges only in a subpopulation of ageing women.
Danuzia Ambrozio‐Marques   +4 more
wiley   +1 more source

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction

open access: yesExperimental Physiology, EarlyView.
Abstract Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%–49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF‐associated exercise intolerance are limited. Nitric oxide (NO)‐independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance ...
Ramona E. Weber   +10 more
wiley   +1 more source

Microelectrode recordings from the human cervical vagus nerve during maximal breath‐holds

open access: yesExperimental Physiology, EarlyView.
Abstract Voluntary breath‐holds can be sustained for a long time following training, but ultimately, regardless of duration, the asphyxic break‐point is reached and the apnoea terminated. The physiological changes occurring during the apnoea include a marked increase in sympathetically‐mediated vasoconstriction in non‐essential organs, such as skeletal
Vaughan G. Macefield   +7 more
wiley   +1 more source

Physiology of nitrogen: A life or death matter

open access: yesExperimental Physiology, EarlyView.
Abstract With each breath, four out of every five molecules we inspire are nitrogen (N2), since this gas constitutes ∼80% of the atmospheric air that surrounds us. Despite its abundance and unlike molecular oxygen, N2 has traditionally held less appeal among physiologists given its lack of reactivity and corresponding inability to support combustion or
Damian M. Bailey   +2 more
wiley   +1 more source

Sex differences in cerebral blood flow and cardiac function in response to exercise in the heat

open access: yesExperimental Physiology, EarlyView.
Abstract We investigated the effect of exercising in hot conditions on cerebral blood flow and systolic left ventricular (LV) function in males and females, to explore sex differences. The experimental condition consisted of walking on a treadmill at 5 km/h and 2% incline, inside a heat chamber at 40°C (50% relative humidity), for 90 min.
João Carlos Locatelli   +13 more
wiley   +1 more source

Carotid artery dissection linked to intermittent apnoeic swimming: A case–control study

open access: yesExperimental Physiology, EarlyView.
Abstract Internal carotid artery (ICA) dissection is a rare and potentially devastating cause of cerebral ischaemia, initiated by an intimal tear or rupture of the vasa vasorum, that can lead to an intraluminal thrombus, vascular stenosis, occlusion, or dissecting aneurysm formation.
Damian M. Bailey   +14 more
wiley   +1 more source

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

open access: yesExperimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li   +2 more
wiley   +1 more source

Predicting symptomatic carotid artery plaques with radiomics-based carotid perivascular adipose tissue characteristics: a multicenter, multiclassifier study. [PDF]

open access: yesBMC Med Imaging
Zhao T   +13 more
europepmc   +1 more source

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