Results 111 to 120 of about 768,176 (386)

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li, Xiaochen Zhang, Jiangwei Xia, Shuang Liu, Yushan Du, Sihan Li, Shukui Zhang, Yong Zhang, Fen Ji, Jianwei Jiao, Jingjing Zhang   +10 more
wiley   +1 more source

Images in cardiovascular medicine : multiphoton microscopy for three-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery [PDF]

, 2007
Two recent elegant studies have shown that in apolipoprotein-E– deficient mice, the lamina adventitia is a major site of arterial wall inflammation associated with lymphocyte infiltration into atherosclerotic arteries and with formation of adventitial ...
Baker, Andrew H., Brewer, James M., Garside, Paul, Ialenti, Armando, Kennedy, Simon, Maffia, Pasquale, McInnes, Iain B., Zinselmeyer, Bernd H.   +7 more
core   +1 more source

Neuroprotective Nanoplatform Integrating Antioxidant MXene Nanozymes and Ferroptosis Inhibitors for Targeted Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Cerebral ischemia‐reperfusion injury (CIRI) is a key pathological process limiting the efficacy of stroke therapy. This study has developed an innovative, multifunctional, brain‐targeted nanoplatform (RFP) containing MXene nanoenzymes and ferroptosis inhibitors.
Lu Wang, Chao Hou, Shuo Li, Lizhi Yang, Yiqun Lin, Sen Wang, Xiaohua Jia, Hui Hui, Wen He, Wei Zhang   +9 more
wiley   +1 more source

Linking cardiorespiratory fitness classification criteria to early subclinical atherosclerosis in children [PDF]

, 2014
It is unclear if cardiorespiratory fitness (CRF) can be used as a screening tool for premature changes in carotid intima-media thickness (cIMT) in paediatric populations.
Fernhall, Bo, Melo, Xavier, Minderico, Cláudia S., Pimenta, Nuno M., Santa-Clara, Helena, Santos, Diana, Sardinha, Luís B.   +6 more
core   +1 more source

European society for vascular surgery (ESVS) 2023 Clinical practice guidelines on the management of atherosclerotic carotid and vertebral artery disease.

European Journal of Vascular and Endovascular Surgery, 2022
A. Naylor, B. Rantner, S. Ancetti, G. D. de Borst, M. De Carlo, A. Halliday, S. Kakkos, H. Markus, D. McCabe, H. Sillesen, J. C. van den Berg, M. Vega de Céniga, M. Venermo, F. Vermassen, R. Naylor, B. Rantner, S. Ancetti, G. D. de Borst, M. De Carlo, A. Halliday, S. Kakkos, H. Markus, D. McCabe, H. Sillesen, J. C. van den Berg, M. D. de Céniga, M. Venermo, F. Vermassen, A. G., Bastos Goncalves F, M. Björck, N. Chakfé, R. Coscas, N. Dias, F. Dick, R. Hinchliffe, P. Kolh, I. Končar, J. Lindholt, B. Mees, T. Resch, S. Trimarchi, R. Tulamo, C. Twine, A. Wanhainen, G. Antoniou, F. Gonçalves, M. Bjorck, N. Chakfé, R. Coscas, N. Dias, F. Dick, R. Hinchliffe, P. Kolh, I. Končar, J. Lindholt, B. Mees, T. Resch, S. Trimarchi, R. Tulamo, C. Twine, A. Wanhainen, S. Bellmunt, R. Bulbulia, C. Darling, H. Eckstein, A. Giannoukas, M. Koelemay, D. Lindström, M. Schermerhorn, D. Stone, S. Bellmunt-Montoya, R. Bulbulia, R. Clement Darling, H. Eckstein, A. Giannoukas, M. Koelemay, D. Lindström, M. Schermerhorn, D. Stone   +79 more
semanticscholar   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

The role of biomechanics in the assessment of carotid atherosclerosis severity: a numerical approach [PDF]

, 2018
Numerical fluid biomechanics has been proved to be an efficient tool for understanding vascular diseases including atherosclerosis. There are many evidences that atherosclerosis plaque formation and rupture are associated with blood flow ...
Bou-said, Benyebka, Culla, Antonio, Massi, Francesco, Millon, Antoine, Zouggari, Lina   +4 more
core  

Ultrasound IMT measurement on a multi-ethnic and multi-institutional database: Our review and experience using four fully automated and one semi-automated methods [PDF]

, 2012
Automated and high performance carotid intima-media thickness (IMT) measurement is gaining increasing importance in clinical practice to assess the cardiovascular risk of patients. In this paper, we compare four fully automated IMT measurement techniques
Andrew Nicolaides, Anil, T., Guang Zeng, Jasjit, S., Kristen, M., Ledda, Giuseppe, Molinari, Filippo, Rajendra Acharya, U., Saba, Luca, Sin Yee Stella Ho, Suzanne, C.   +10 more
core   +1 more source

Biomimetic Multiscale‐Structured Biomass Graphene/Polyurethane Sponge Composite for Flexible Pressure Sensors and Intelligent Cushioning Materials

Advanced Science, EarlyView.
In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu, Pusen Cao, Tingting Zhang, Jie Wei, Yue Wang, Zhi Huang, Zhenghang Chen, Jianfeng Xi, Yong Guo, Yuxia Chen   +9 more
wiley   +1 more source

Evaluate the elasticity of carotid artery in the type 2 diabetes mellitus patients with nonalcoholic fatty liver disease by two-dimensional strain imaging

, 2022
Zhen Li, Xin Mao, Xiuxiu Cui, Tingting Yu, Mengmeng Zhang, Xiya Li, Guangsen Li   +6 more
openalex   +1 more source