Results 131 to 140 of about 636,322 (300)

Safety, Tolerability, and Pharmacokinetics of Donanemab in Healthy Chinese Participants: A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Alzheimer's disease (AD), characterized by β‐amyloid (Aβ) plaques and neurofibrillary tangles, is the leading cause of dementia globally. Donanemab is a humanized immunoglobulin G1 in development as a treatment to slow AD progression. This study aimed to evaluate the safety, tolerability, pharmacokinetics (PKs), and immunogenicity of donanemab
Junyu Xu, Nan Zhao, Yihui Wang, Ivelina Gueorguieva, Chenxi Qian, Yimin Cui   +5 more
wiley   +1 more source

The relative contributions of aortic and carotid artery stiffness to CeVD and cognition

Cerebral Circulation - Cognition and Behavior
Introduction: The relative contributions of aortic and carotid artery stiffness on cognitive impairment and dementia remain unknown. We examined the associations of aortic and carotid artery stiffness with cerebrovascular disease markers, cognition, and ...
Caroline Robert, Lieng-Hsi Ling, Eugene Tan, Narayanaswamy Venketasubramanian, Shir Lynn Lim, Lingli Gong, Josephine Berboso, Arthur Mark Richards, Christopher Chen, Chuen Seng Tan, Saima Hilal   +10 more
doaj  

Sex-specific ultrasound imaging biomarkers of neurodegeneration in a mouse model

Frontiers in Aging Neuroscience
IntroductionEarly detection of neurodegeneration is essential for optimizing interventions. The highly reproducible progression of neurodegeneration in the decrepit (dcr) mouse allows investigation of early biomarkers and mechanisms of brain injury ...
Mark B. Russell, Drew P. Locke, Haley M. Adams, Alexander R. Pelley, Rojan Saghian, Rojan Saghian, Alexandre S. Maekawa, Darcie Stapleton, Grace V. Mercer, John G. Sled, John G. Sled, John G. Sled, Lindsay S. Cahill, Lindsay S. Cahill   +13 more
doaj   +1 more source

Contribution of UltraFast™ Ultrasound and Shear Wave Elastography in the Imaging of Carotid Artery Disease. [PDF]

Diagnostics (Basel), 2022
Bulum A, Ivanac G, Mandurić F, Pfeifer L, Bulum M, Divjak E, Radoš S, Brkljačić B.   +7 more
europepmc   +1 more source

Squamate ventricular cardiomyocytes: Ploidy, proliferation, and heart muscle cell size in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Abstract Background While heart function is broadly conserved across vertebrates, the cellular phenotype of muscle cells (cardiomyocytes) varies across taxa and throughout ontogeny. Emerging evidence suggests that some attributes may correlate with the capacity for spontaneous cardiomyocyte replacement following injury.
Kathy Jacyniak, Karemna Barrera Jaimes, Minh Hanh Doan, Jordyn M. Chartrand, Matthew K. Vickaryous   +4 more
wiley   +1 more source

The quality of guidelines for treatment of carotid artery disease: a critical appraisal using the AGREE II instrument. [PDF]

J Vasc Bras, 2022
Coutinho SGB, Ricardo JC, Coutinho AIM, Cavalcante LP.   +3 more
europepmc   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Multivariate linear regression to predict association of non‐invasive arterial stiffness with cardiovascular events

ESC Heart Failure, Volume 12, Issue 2, Page 1141-1150, April 2025.
Abstract Background Arterial stiffness is a crucial factor in determining an increase in systolic blood pressure and pulse pressure and can also predict the development of cardiovascular disease (CVD). The purpose of this study was to examine the relationship between arterial stiffness and future CVD.
Susan Darroudi, Mostafa Eslamiyeh, Amin Mansoori, Eisa Nazar, Maryam Alinezhad‐Namaghi, Reza Rezvani, Majid Ghayour‐Mobarhan, Habibollah Esmaily, Mohsen Moohebati, Gordon A. Ferns, Mark Ghamsary   +10 more
wiley   +1 more source

Additional value of inflammatory biomarkers and carotid artery disease in prediction of significant coronary artery disease as assessed by coronary computed tomography angiography

European Heart Journal-Cardiovascular Imaging, 2017
A. Guaricci, G. Pontone, L. Fusini, M. De Luca, F. Cafarelli, M. Guglielmo, A. Baggiano, V. Beltrama, G. Muscogiuri, S. Mushtaq, E. Conte, G. Guglielmi, D. Andreini, N. Brunetti, M. di Biase, A. Bartorelli, M. Pepi   +16 more
semanticscholar   +1 more source

Carotid artery endarterectomy in patients with symptomatic non-stenotic carotid artery disease. [PDF]

Stroke Vasc Neurol, 2022
Nardi V, Benson JC, Larson AS, Brinjikji W, Saba L, Meyer FB, Lanzino G, Lerman A, Savastano LE.   +8 more
europepmc   +1 more source