Results 321 to 330 of about 748,567 (397)

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Serious outcomes among emergency department patients with presyncope: A systematic review

Academic Emergency Medicine, EarlyView.
Abstract Background Syncope is transient loss of consciousness, and in presyncope, patients experience same prodromal symptoms without losing consciousness. While studies have extensively reported the risk of serious outcome among emergency department (ED) syncope, the outcome for patients with presyncope and their management are not well studied.
Hadi Mirfazaelian, Ian Stiell, Rasoul Masoomi, Khazar Garjani, Venkatesh Thiruganasambandamoorthy   +4 more
wiley   +1 more source

Prenatal alcohol exposure worsens acute but not long‐term cognitive outcomes due to stroke in middle‐aged Sprague–Dawley rat offspring

Alcohol, Clinical and Experimental Research, EarlyView.
Adults with prenatal alcohol exposure (PAE) are at increased risk for metabolic, immune, and cardiovascular disease. Little is known about the contribution of PAE to cerebrovascular disease, specifically during middle age, a time when stroke incidence and severity typically increase.
Shameena Bake, Marisa R. Pinson, David A. Hurst, Brendan O'Reilly, Nadia Samiya, Rajesh C. Miranda, Farida Sohrabji   +6 more
wiley   +1 more source

Genetic Determinants of the Familial Hypercholesterolaemia Phenotype

Annals of Human Genetics, EarlyView.
ABSTRACT Individuals with familial hypercholesterolaemia (FH) have severely elevated plasma concentrations of low‐density lipoprotein cholesterol (LDL‐C) from birth and as a consequence have an elevated morbidity and mortality due to the development of coronary heart disease (CHD).
Steve Eric Humphries, Marta Futema
wiley   +1 more source

Therapeutic potential of hesperidin in diabetes mellitus‐induced erectile dysfunction through Nrf2‐mediated ferroptosis and oxidative stress

Andrology, EarlyView.
Abstract Background Among erectile dysfunction (ED) caused by metabolic abnormalities, diabetes mellitus‐induced ED (DMED) progresses rapidly, manifests with severe symptoms, and shows reduced responsiveness to conventional medications. Hyperglycemia in the corpus cavernosum has been linked to the induction of both ferroptosis and oxidative stress ...
Sheng Xin, Wen Song, Jiaquan Mao, Peng Hu, Zhong Chen, Jihong Liu, Xiaodong Song, Qian Fang, Kai Cui   +8 more
wiley   +1 more source

Penile vascular status in young men living with HIV experiencing erectile dysfunction: A comparative cross‐sectional pilot study

Andrology, EarlyView.
Abstract Background Erectile dysfunction in people living with HIV is a multifactorial disease, but the role of penile vascular status assessed by dynamic penile color Doppler echography is underexplored. Objectives This study assessed penile vascular status in young males living with HIV experiencing erectile dysfunction, comparing them to HIV ...
Giorgio Tiecco, Andrea Delbarba, Cosimo Colangelo, Marco Di Gregorio, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros‐Roldan   +9 more
wiley   +1 more source

Carotid Endarterectomy Versus Carotid Artery Stenting: Survey of the Quality, Readability, and Treatment Preference of Carotid Artery Disease Websites.

Interact J Med Res, 2020
Strauss S, Yacob M, Bhandari A, Jetty P.
europepmc   +1 more source

Changing Trends in Carotid Revascularization in Australia: A Nationwide Study Over 30 Years

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Carotid artery stenosis is one of the causes of acute ischaemic stroke. Carotid endarterectomy (CEA) and carotid artery stenting (CAS) are the main procedural treatment options. This study investigates the changing trends in carotid revascularisation in Australia over the last 30 years.
David F. Sun, Kevin Tian, Amanda Seneviratne, Oh Sung Choy, Daphne Wang, Vimalin Vedanayagam, Michelle T. Sun, Christopher X. Wong   +7 more
wiley   +1 more source

Investigating M101's Effect in Improving Cardiac and Diaphragmatic Mechanical and Functional Properties on Wistar Rat

Artificial Organs, EarlyView.
M101 Hemoglobin enhances the mechanical and functional properties of rat heart and diaphragm muscles. Treated muscles exhibit improved contraction, reduced fatigue, and maintained function over time, suggesting potential clinical applications of M101 in preventing ischemia–reperfusion injury.
Ollivier Grimault, Michael Theron, Quentin Boete, Mathieu Maalouf, Jean‐Baptiste Quéméneur, Franck Zal, Karelle Léon, Karine Pichavant‐Rafini   +7 more
wiley   +1 more source

Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs

Artificial Organs, EarlyView.
This pig model of simultaneous perfusion of paired kidneys in normothermia suggests that intra‐individual variation is relatively low, enabling one kidney to be employed as a reliable comparator of the other kidney for assessing treatments before kidney transplantation.
Margaux Navez, Nicholas Gilbo, Morgan Vandermeulen, Tiago Pinto Coelho, Pauline Erpicum, Marc Gilbert Lagny, Clarisse Malisoux, Claire Guarin, Gabriel Thierry, Pierre Delanaye, Etienne Cavalier, François Jouret, Olivier Detry   +12 more
wiley   +1 more source