Results 221 to 230 of about 176,708 (300)

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

open access: yesThe FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin   +2 more
wiley   +1 more source

Returning to Exercise After Valsalva-Induced Carotid Artery Dissection. [PDF]

open access: yesJACC Case Rep
Gutzwiller L   +9 more
europepmc   +1 more source

Final Analysis of the Phase 1/2 Trial of Valoctocogene Roxaparvovec for Severe Haemophilia A

open access: yesHaemophilia, EarlyView.
ABSTRACT Introduction Valoctocogene roxaparvovec is an adeno‐associated virus vector serotype 5 (AAV5)‐mediated gene therapy for severe haemophilia A (HA). Aim Report the final safety and efficacy results of the phase 1/2 trial of valoctocogene roxaparvovec. Methods An open‐label phase 1/2 trial (NCT02576795) enrolled adult males with severe HA (factor
Priyanka Raheja   +9 more
wiley   +1 more source

Carotid arteries in cerebral small vessel disease and dementia. [PDF]

open access: yesActa Neuropathol Commun
Kitajima E   +12 more
europepmc   +1 more source

Improved prognosis prediction of all‐cause mortality and cardiovascular events by combined assessment of both ankle‐brachial index and brachial‐ankle pulse wave velocity in individuals with diabetes: The Kyushu prevention study for atherosclerosis, a prospective, multicenter survey

open access: yesJournal of Diabetes Investigation, EarlyView.
A novel algorithm combining ABI and baPWV was developed to predict mortality and CVD risk in individuals with diabetes. This algorithm improved the accuracy of mortality and CVD risk assessment and was independent from the Framingham Risk Score. ABSTRACT Aims/Introduction People with diabetes exhibit early‐stage cardiovascular disease (CVD).
Erina Eto   +6 more
wiley   +1 more source

Internal carotid artery involvement and stroke risk in Takayasu arteritis: a case-control study. [PDF]

open access: yesRheumatol Int
Bukun HO   +7 more
europepmc   +1 more source

3D transparent technology displays the developmental patterns of ductus arteriosus morphology in chicken embryos before and after birth

open access: yesJournal of Anatomy, EarlyView.
At the eighth week of human embryonic development, 3D transparent imaging enables clear visualization of the outflow tract's morphological features, revealing its anatomical components in detail. Abstract The ductus arteriosus (DA) is a critical fetal vascular structure that shunts blood from the pulmonary artery to the aorta, bypassing the non ...
Conghong Xu   +7 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

open access: yesJournal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini   +3 more
wiley   +1 more source

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