Results 121 to 130 of about 26,261 (234)

Two tumours of the carotid bifurcation.

open access: yesAnnals of the Academy of Medicine, Singapore, 1981
Two cases of tumours of the carotid bifurcation are reported here with the objective of outlining a rational approach to their management. A review of the literature confirms that the bad results of surgical treatment are largely due to jeopardization of the carotid circulation at the time of operation.
R C, Ngim, G, Baratham
openaire   +1 more source

E3 Ubiquitin Ligase NEDD4‐Mediated CTSB Ubiquitination Prevents Microglial Ferroptosis After Subarachnoid Hemorrhage

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
NEDD4 attenuates secondary brain injury after SAH by ubiquitinating and degrading CTSB, thereby inhibiting microglial ferroptosis. ABSTRACT To investigate the role of cathepsin B (CTSB) in microglial ferroptosis after subarachnoid hemorrhage (SAH) and its upstream regulatory mechanisms.
Xiuyou Yan   +6 more
wiley   +1 more source

α‐Synuclein Promotes Atherosclerosis by Impairing Macrophage Autophagic Flux

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Extracellular α‐synuclein activates the FLOT1‐PI3K‐mTOR axis to block autophagosome‐lysosomal fusion and lipophagy, thereby promoting macrophage foaming and atherosclerosis. Knockdown of FLOT1 or inhibition of PI3K‐mTOR rescues these effects. The graphical abstract image was created with Figdraw.
Mengting Qin   +8 more
wiley   +1 more source

Influence of wall distensibility on local hemodynamics at the normal carotid bifurcation: a fluid-structure interaction study. [PDF]

open access: yesBiomech Model Mechanobiol
Zambon S   +8 more
europepmc   +1 more source

Exercise and Autonomic Cardiovascular Function—Insights From Spinal Cord‐Injured Humans: A Narrative Review

open access: yesActa Physiologica, Volume 242, Issue 10, October 2026.
ABSTRACT The cardiovascular response to acute exercise is mediated by the autonomic nervous system (ANS) control mechanisms that modulate vascular resistance to support blood pressure and ensure adequate blood flow to active muscles. These autonomic neurocirculatory control mechanisms include a feedforward mechanism, known as central command, and three
Rasmus Kopp Hansen   +5 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, Volume 13, Issue 50, 7 September 2026.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng   +14 more
wiley   +1 more source

Extracellular CIRP Dysregulates Microglial Efferocytosis in Acute Ischemic Stroke via the TLR4/miR‐155/MafB Axis

open access: yesAdvanced Science, Volume 13, Issue 53, 24 September 2026.
eCIRP released in the stroke brain binds to TLR4 expressed on microglia to induce miR‐155, which suppresses MafB, decreases MerTK and downstream signaling to impair efferocytosis of apoptotic neurons, worsening the acute stroke outcomes. Inhibition of eCIRP‐TLR4 interaction with small peptide C23 attenuates eCIRP‐induced microglial efferocytic ...
Dmitriy Lapin   +3 more
wiley   +1 more source

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