Results 61 to 70 of about 101,468 (338)
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Nature Communications, 2018 Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,N. Franceschini, C. Giambartolomei, P. D. de Vries, C. Finan, J. Bis, R. Huntley, R. Lovering, S. Tajuddin, T. Winkler, M. Graff, M. Kavousi, C. Dale, A. Smith, E. Hofer, E. V. van Leeuwen, I. Nolte, Lingyi Lu, M. Scholz, M. Sargurupremraj, N. Pitkänen, Oscar Franzén, Peter K. Joshi, R. Noordam, R. Marioni, Shih-Jen Hwang, S. Musani, U. Schminke, W. Palmas, A. Isaacs, A. Correa, A. Zonderman, A. Hofman, A. Teumer, A. Cox, A. Uitterlinden, A. Wong, A. Smit, A. Newman, A. Britton, A. Ruusalepp, B. Sennblad, B. Hedblad, B. Pasaniuc, B. Penninx, C. Langefeld, C. Wassel, C. Tzourio, C. Fava, D. Baldassarre, D. O'leary, D. Teupser, D. Kuh, E. Tremoli, E. Mannarino, E. Grossi, E. Boerwinkle, E. Schadt, E. Ingelsson, F. Veglia, F. Rivadeneira, F. Beutner, G. Chauhan, G. Heiss, H. Snieder, H. Campbell, H. Völzke, H. Markus, I. Deary, J. Jukema, J. de Graaf, J. Price, Janne Pott, J. Hopewell, Jingjing Liang, J. Thiery, J. Engmann, K. Gertow, K. Rice, K. Taylor, K. Dhana, L. Kiemeney, L. Lind, L. Raffield, L. Launer, L. Holdt, M. Dörr, M. Dichgans, M. Traylor, M. Sitzer, M. Kumari, M. Kivimaki, M. Nalls, O. Melander, O. Raitakari, O. Franco, O. Rueda-Ochoa, Panagiotis Roussos, P. Whincup, P. Amouyel, P. Giral, Pramod Anugu, Q. Wong, R. Malik, R. Rauramaa, R. Burkhardt, R. Hardy, R. Schmidt, R. de Mutsert, R. Morris, R. Strawbridge, S. Wannamethee, S. Hägg, Sonia H. Shah, S. McLachlan, S. Trompet, S. Seshadri, S. Kurl, S. Heckbert, S. Ring, T. Harris, T. Lehtimäki, T. Galesloot, T. Shah, U. de Faire, V. Plagnol, W. Rosamond, W. Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Y. Saba, Yukinori Aniket Loes Anne-Katrin Sander W. Solveig Christop Okada Mishra Rutten-Jacobs Giese van der Laan Gret, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, Traci M. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, I. Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, S. Gustafsson, J. Haessler, Ahamad Hassan, A. Havulinna, E. Holliday, G. Howard, F. Hsu, H. Hyacinth, M. Ikram, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, T. Mosley, T. Ninomiya, M. O’Donnell, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, S. Rich, P. Ridker, N. Rost, P. Rothwell, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, M. Walters, N. Wareham, S. Wassertheil-Smoller, K. Wiggins, Qiong Yang, S. Yusuf, T. Pastinen, E. Schadt, Simon Koplev, Veronica Codoni, M. Civelek, Nick Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, J. Howson, Y. Kamatani, A. Dehghan, A. Seldenrijk, A. Morrison, A. Hamsten, B. Psaty, C. V. van Duijn, D. Lawlor, D. Mook-Kanamori, D. Bowden, H. Schmidt, James F. Wilson, James G. Wilson, J. Rotter, J. Wardlaw, J. Deanfield, J. Halcox, L. Lyytikäinen, M. Loeffler, M. Evans, S. Debette, S. Humphries, U. Völker, V. Gudnason, A. Hingorani, J. Björkegren, J. Casas, C. O’Donnell +299 moresemanticscholar +1 more sourceTargeted 2‐Deoxy‐D‐Ribose Delivery by Biomimetic Nanoplatform Activates EGFR for Accelerated Heart Valve Endothelialization
Advanced Science, EarlyView.This study develops a biomimetic nanoplatform using erythrocyte membrane‐camouflaged, CD144 antibody‐functionalized nanoparticles to deliver 2‐deoxy‐D‐ribose (2dDR). This system promotes heart valve endothelialization by enhancing endothelial cell migration and proliferation via EGFR activation, while improving hemocompatibility.Xiang Qiu, Gaofeng Li, Wenyi Wan, Jinsheng Li, Ge Yan, Shijie Wang, Xiuqi Hu, Zongqi Han, Yazheng Shan, Ying Zhou, Nianguo Dong, Weihua Qiao +11 morewiley +1 more sourceCarotid Atherosclerosis and Cerebral Microbleeds: The Framingham Heart Study
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016 BackgroundCarotid atherosclerosis is associated with subclinical ischemic cerebrovascular disease, but its role in hemorrhage‐prone small vessel disease—represented by cerebral microbleed (CMB)—is unclear, although vascular risk factors underlie both ...José R. Romero, Sarah R. Preis, Alexa Beiser, Charles DeCarli, Ralph B. D'Agostino, Philip A. Wolf, Ramachandran S. Vasan, Joseph F. Polak, Sudha Seshadri +8 moredoaj +1 more sourceRough Set Based Approach for IMT Automatic Estimation [PDF]
, 2012 Carotid artery (CA) intima-media thickness (IMT) is commonly deemed as one of the risk marker for cardiovascular diseases. The automatic estimation of the IMT on ultrasound images is based on the correct identification of the lumen-intima (LI) and media ...Balestra, Gabriella, Molinari, Filippo, Rosati, Samanta +2 morecore Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification
Advanced Science, EarlyView.This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou +13 morewiley +1 more sourceLeucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages
Advanced Science, EarlyView.Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian +22 morewiley +1 more source
