Results 31 to 40 of about 43,395 (223)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China

Frontiers in Endocrinology, 2022
ContextPrevious studies on the association between thyroid function and carotid plaque have shown contradictory results, which may be attributable to the sensitivity to thyroid hormone indices.
Yijia Liu, Zhu Li, Tong Yang, Lin Li, Lu Yu, Fanfan Liu, Tongyao Ni, Shan Gao, Chunjie Li, Rongrong Yang, Chunquan Yu   +10 more
doaj   +1 more source

Modern Management of Asymptomatic Carotid Stenosis: A Meta‐Analysis of CREST‐2, SPACE‐2, and ECST‐2

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Recent randomized trials (CREST‐2, SPACE‐2, and ECST‐2) have compared carotid revascularization (carotid endarterectomy [CEA] or carotid artery stenting [CAS]) plus contemporary medical therapy (CMT) versus CMT alone in asymptomatic carotid stenosis.
Aasim Ali, Waqar Ahmed Cheema, Fiza Nisar, Muhammad Shamoon, Sameen Sarfaraz, Ahmad Butt, Muhammad Abdullah Ali, Armaghana Abdullah, Muhammad Asad Shabbir, Muhammad Talha, Hammad Azam, Aimen Anwaar Pannun, Usama Saleem, Anousha Tanveer, Mukesh Sharma   +14 more
wiley   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Detection rate and influencing factors of carotid plaque and plaque burden in the population with the age ≥ 40 years and high stroke risk from 2017 to 2020 in Nanjing city: based on CNSSS data analysis

Zhongguo gonggong weisheng
ObjectiveTo investigate the detection rate and influencing factors of carotid plaque and plaque burden in a population with the age ≥ 40 years and high stroke risk in Nanjing city, thereby providing evidence for stroke prevention and control. MethodsAs a
Shengxiang QI, Zhenzhen QIN, Lan CUI, Jinyi ZHOU, Xin HONG   +4 more
doaj   +1 more source

Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The association between common carotid artery intima‐media thickness (CCA‐IMT) and incident carotid plaque has not been characterized fully.
Lena Tschiderer, Lisa Seekircher, Raffaele Izzo, Costantino Mancusi, Maria V. Manzi, Damiano Baldassarre, Mauro Amato, Elena Tremoli, Fabrizio Veglia, Tomi‐Pekka Tuomainen, Jussi Kauhanen, Ari Voutilainen, Bernhard Iglseder, Lars Lind, Tatjana Rundek, Moise Desvarieux, Akihiko Kato, Eric de Groot, Gülay Aşçi, Ercan Ok, Stefan Agewall, Joline W. J. Beulens, Christopher D. Byrne, Philip C. Calder, Hertzel C. Gerstein, Paolo Gresele, Gerhard Klingenschmid, Michiaki Nagai, Michael H. Olsen, Grace Parraga, Maya S. Safarova, Naveed Sattar, Michael Skilton, Coen D. A. Stehouwer, Heiko Uthoff, Michiel A. van Agtmael, Amber A. van der Heijden, Dorota A. Zozulińska‐Ziółkiewicz, Hyun‐Woong Park, Moo‐Sik Lee, Jang‐Ho Bae, Oscar Beloqui, Manuel F. Landecho, Matthieu Plichart, Pierre Ducimetiere, Jean Philippe Empana, Lena Bokemark, Göran Bergström, Caroline Schmidt, Samuela Castelnuovo, Laura Calabresi, Giuseppe D. Norata, Liliana Grigore, Alberico Catapano, Dong Zhao, Miao Wang, Jing Liu, M. Arfan Ikram, Maryam Kavousi, Michiel L. Bots, Michael J. Sweeting, Matthias W. Lorenz, Peter Willeit   +62 more
doaj   +1 more source

Can Carotid Plaque Predict Coronary Plaque?

JACC: Cardiovascular Imaging, 2013
Atherothrombotic occlusive vascular disease is a leading cause of acute cardiovascular events (acute coronary syndromes, sudden death, and ischemic stroke). Therapeutic lifestyle modification, medical therapy to control risk factors, and, in selected cases, revascularization by percutaneous ...
openaire   +2 more sources

The unstable carotid plaque. [PDF]

Stroke, 1989
However, neurologic outcome correlated highly with acute local changes in large, severely stenosing, unstable plaques, and a correlation also exists with progression or regression, possibly reflecting plaque instability.
N M, Bornstein, J W, Norris
openaire   +2 more sources

A Threshold Study of Carotid Plaque Risk in Postmenopausal Middle-aged Women with Normal Homocysteine [PDF]

Zhongguo quanke yixue
Background Carotid plaque is an important early predictive signal of clinical carotid atherosclerosis, the association between homocysteine (Hcy) and carotid plaque is well recognized, however, the correlation between Hcy and carotid plaque in ...
LU Ran, WU Chunyan, XU Haina, AN Miaomiao, WU Baoqin, LAI Jun, RAN Limei
doaj   +1 more source