Results 61 to 70 of about 551,509 (302)

Monocyte‐Differentiation‐Activated Fluorescent “Scout” Probe for Precise in Vivo Detection of Vulnerable Plaque

Advanced Science, EarlyView.
An innovative monocyte‐differentiation‐activated fluorescent “scout” probe (MDAF) leverages the inherent chemotaxis of monocytes toward vulnerable plaques (VAP) to enable efficient targeted delivery while achieving spatiotemporally controllable activation of its AIE fluorescent signals with the dynamic differentiation of monocytes, providing an ...
Zechuan Li, Jiankai Dong, Zhengkun Liu, Chaoke Zhang, Jisen Li, Ying Tao, Ding Yang, Yansong Liu, Haoting Chen, Lu Liu, Jingsen Ji, Feng Cao, Dan Ding, Qian Liu, Chenxing Fu, Weisheng Guo   +15 more
wiley   +1 more source

Associations of plaque morphology and location with Intraplaque neovascularization in the carotid artery by contrast-enhanced ultrasound imaging

Frontiers in Neurology, 2023
ObjectiveIntraplaque neovascularization (IPN) is a known indicator of plaque vulnerability, and is thus considered a predictor of stroke. The morphology and location of the carotid plaque may be correlated with plaque vulnerability.
Shi-Yao Gu, Lu-Ni Zhang, Jing Chen, Fang Li, Ming-Hua Yao, Cai-Xia Jia, Rong Wu   +6 more
doaj   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

Association between weight-adjusted waist index and carotid atherosclerotic plaque in patients with type 2 diabetes in the Chinese population

Diabetology & Metabolic Syndrome
Purpose The purpose of this study is to investigate the relationship between the weight-adjusted waist index (WWI) and the incidence of carotid atherosclerotic plaque in patients with type 2 diabetes (T2DM) in the Chinese population.
Yu Qin, Jing-Jing Ye, Xu-Nan Wu, Yue Xia, Hao-Xiang Li, Ling Yang, Xia Deng, Guo-Yue Yuan   +7 more
doaj   +1 more source

Relations of lipid parameters, other variables with carotid intima-media thickness and plaque in the general Chinese adults: an observational study

Lipids in Health and Disease, 2018
Background It has been reported that non-high-density lipoprotein cholesterol (non-HDL-C) and lipid ratios, including total cholesterol (TC) / high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) / HDL-C, are ...
Qingtao Hou, Sheyu Li, Yun Gao, Haoming Tian   +3 more
doaj   +1 more source

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Nature Communications, 2018
Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,
N. Franceschini, C. Giambartolomei, P. D. de Vries, C. Finan, J. Bis, R. Huntley, R. Lovering, S. Tajuddin, T. Winkler, M. Graff, M. Kavousi, C. Dale, A. Smith, E. Hofer, E. V. van Leeuwen, I. Nolte, Lingyi Lu, M. Scholz, M. Sargurupremraj, N. Pitkänen, Oscar Franzén, Peter K. Joshi, R. Noordam, R. Marioni, Shih-Jen Hwang, S. Musani, U. Schminke, W. Palmas, A. Isaacs, A. Correa, A. Zonderman, A. Hofman, A. Teumer, A. Cox, A. Uitterlinden, A. Wong, A. Smit, A. Newman, A. Britton, A. Ruusalepp, B. Sennblad, B. Hedblad, B. Pasaniuc, B. Penninx, C. Langefeld, C. Wassel, C. Tzourio, C. Fava, D. Baldassarre, D. O'leary, D. Teupser, D. Kuh, E. Tremoli, E. Mannarino, E. Grossi, E. Boerwinkle, E. Schadt, E. Ingelsson, F. Veglia, F. Rivadeneira, F. Beutner, G. Chauhan, G. Heiss, H. Snieder, H. Campbell, H. Völzke, H. Markus, I. Deary, J. Jukema, J. de Graaf, J. Price, Janne Pott, J. Hopewell, Jingjing Liang, J. Thiery, J. Engmann, K. Gertow, K. Rice, K. Taylor, K. Dhana, L. Kiemeney, L. Lind, L. Raffield, L. Launer, L. Holdt, M. Dörr, M. Dichgans, M. Traylor, M. Sitzer, M. Kumari, M. Kivimaki, M. Nalls, O. Melander, O. Raitakari, O. Franco, O. Rueda-Ochoa, Panagiotis Roussos, P. Whincup, P. Amouyel, P. Giral, Pramod Anugu, Q. Wong, R. Malik, R. Rauramaa, R. Burkhardt, R. Hardy, R. Schmidt, R. de Mutsert, R. Morris, R. Strawbridge, S. Wannamethee, S. Hägg, Sonia H. Shah, S. McLachlan, S. Trompet, S. Seshadri, S. Kurl, S. Heckbert, S. Ring, T. Harris, T. Lehtimäki, T. Galesloot, T. Shah, U. de Faire, V. Plagnol, W. Rosamond, W. Post, Xiaofeng Zhu, Xiaoling Zhang, Xiuqing Guo, Y. Saba, Yukinori Aniket Loes Anne-Katrin Sander W. Solveig Christop Okada Mishra Rutten-Jacobs Giese van der Laan Gret, Y. Okada, A. Mishra, L. Rutten-Jacobs, A. Giese, S. W. van der Laan, S. Gretarsdottir, C. Anderson, M. Chong, H. Adams, T. Ago, P. Almgren, P. Amouyel, H. Ay, Traci M. Bartz, O. Benavente, S. Bevan, G. Boncoraglio, Robert D. Brown, A. Butterworth, C. Carrera, C. Carty, D. Chasman, Wei-Min Chen, J. Cole, I. Cotlarciuc, Carlos Cruchaga, J. Danesh, P. D. de Bakker, A. Destefano, M. den Hoed, Qing Duan, S. Engelter, G. Falcone, R. Gottesman, R. Grewal, S. Gustafsson, J. Haessler, Ahamad Hassan, A. Havulinna, E. Holliday, G. Howard, F. Hsu, H. Hyacinth, M. Ikram, M. Irvin, X. Jian, J. Jiménez-Conde, Julie A. Johnson, J. Jukema, M. Kanai, Keith L. Keene, B. Kissela, D. Kleindorfer, C. Kooperberg, M. Kubo, L. Lange, C. Langefeld, C. Langenberg, J. Lee, R. Lemmens, D. Leys, C. Lewis, Wei-Yu Lin, A. Lindgren, E. Lorentzen, P. Magnusson, J. Maguire, A. Manichaikul, P. McArdle, J. Meschia, T. Mosley, T. Ninomiya, M. O’Donnell, S. Pulit, Kristiina Rannikmäe, A. Reiner, K. Rexrode, S. Rich, P. Ridker, N. Rost, P. Rothwell, T. Rundek, R. Sacco, S. Sakaue, M. Sale, V. Salomaa, B. Sapkota, R. Schmidt, C. Schmidt, U. Schminke, Pankaj Sharma, A. Słowik, C. Sudlow, C. Tanislav, T. Tatlisumak, V. Thijs, G. Thorleifsson, U. Thorsteinsdóttir, S. Tiedt, M. Walters, N. Wareham, S. Wassertheil-Smoller, K. Wiggins, Qiong Yang, S. Yusuf, T. Pastinen, E. Schadt, Simon Koplev, Veronica Codoni, M. Civelek, Nick Smith, D. Trégouët, I. Christophersen, C. Roselli, S. Lubitz, P. Ellinor, E. Tai, J. Kooner, N. Kato, Jiang He, P. van der Harst, P. Elliott, J. Chambers, F. Takeuchi, Andrew D. Johnson, D. Sanghera, C. Jern, D. Strbian, I. Férnandez-Cadenas, W. Longstreth, A. Rolfs, J. Hata, D. Woo, J. Rosand, G. Paré, D. Saleheen, K. Stefánsson, B. Worrall, S. Kittner, J. Howson, Y. Kamatani, A. Dehghan, A. Seldenrijk, A. Morrison, A. Hamsten, B. Psaty, C. V. van Duijn, D. Lawlor, D. Mook-Kanamori, D. Bowden, H. Schmidt, James F. Wilson, James G. Wilson, J. Rotter, J. Wardlaw, J. Deanfield, J. Halcox, L. Lyytikäinen, M. Loeffler, M. Evans, S. Debette, S. Humphries, U. Völker, V. Gudnason, A. Hingorani, J. Björkegren, J. Casas, C. O’Donnell   +299 more
semanticscholar   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

Echolucency of carotid plaques correlates with plaque cellularity [PDF]

European Journal of Vascular and Endovascular Surgery, 2003
To analyse the relationship between carotid plaque echolucency and cellularity.Carotid plaques (14 symptomatic and 16 asymptomatic) were snap frozen after endarterectomy and defined on the basis of their grey-scale-median (GSM), obtained from pre-operative high-definition ultrasonography, as either echolucent (or=32). DNA and total soluble protein were
Gonçalves, I., Moses, J., Pedro, L.M., Dias, N., Fernandes, J.Fernandes e, Nilsson, J., Ares, M.P.S.   +6 more
openaire   +2 more sources

Upregulation of miR-330-5p is associated with carotid plaque’s stability by targeting Talin-1 in symptomatic carotid stenosis patients

BMC Cardiovascular Disorders, 2019
BackgroundThe aim of this study was to investigate the relationship between Talin-1 and stability of carotid atherosclerosis plaque and also find out the role of miRNA, as an upstream regulator, in regulating the expression level of Talin-1.MethodsHuman ...
Xiao-long Wei, Yudong Sun, Tonglei Han, Jiang Zhu, Yongfu Xie, Shiying Wang, Yani Wu, Yinxing Fan, Xiuli Sun, Jian Zhou, Zhiqing Zhao, Z. Jing   +11 more
semanticscholar   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source