Results 171 to 180 of about 5,866 (302)

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Scoping Review of the Socioeconomic Value of Working Equids, and the Impact of Educational Interventions Aimed at Improving Their Welfare. [PDF]

Animals (Basel)
Cameron A, Freeman SL, Wild I, Burridge J, Burrell K.   +4 more
europepmc   +1 more source

Changes in the Prevalence of Infection in Pregnant Women during the COVID-19 Lockdown. [PDF]

Microorganisms, 2023
Werter DE, Schuster HJ, Schneeberger C, Pajkrt E, de Groot CJM, van Leeuwen E, Kazemier BM.   +6 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Outcomes of Fecal Microbiota Transplantation for <i>Clostridioides difficile</i> Infection in South Australia. [PDF]

Open Forum Infect Dis
Tucker EC, Angelica B, Mathias RM, Edwards L, Bryant RV, Costello SP.   +5 more
europepmc   +1 more source

The need for awareness and action in managing nanowaste. [PDF]

Nat Nanotechnol, 2023
Schwab F, Rothen-Rutishauser B, Scherz A, Meyer T, Karakoçak BB, Petri-Fink A.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

HYFF-CB: Hybrid Feature Fusion Visual Model for Cargo Boxes. [PDF]

Sensors (Basel)
Li J, Yang K, Qiu C, Wang L, Cai Y, Wei H, Yu Q, Huang P.   +7 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optimizing international trade: Strategies for retaining or taking over transport remit in Poland's import and export landscape-A case study of Company X. [PDF]

PLoS One
Bednarz J, Grottel M, Sperska A, Cirella GT, Suchanek M, Oniszczuk-Jastrząbek A, Czermanski E.   +6 more
europepmc   +1 more source