Results 101 to 110 of about 29,857,416 (243)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Convex optimization–based multi-user detection in underwater acoustic sensor networks

International Journal of Distributed Sensor Networks, 2018
Multi-carrier code-division multiple access is an important technical means for high-performance underwater acoustic sensor networks. Nevertheless, severe multiple access interference is a huge challenge.
Jianping Wang, Shujing Zhang, Wei Chen, Dechuan Kong, Zhou Yu   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science
Polymeric carriers are gaining increasing attention for the delivery of a range of clinically relevant nucleic acid (NA) payloads, due to their efficacy, safety, and modular chemistry.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From Encapsulation to Food Delivery: Application-Driven Design of Functional Ingredients Using Encapsulation and Coating Approaches for Future Food Systems

Foods
Encapsulation and coating approaches have become important tools in modern food systems for improving the stability, functionality, sensory quality, processability, and controlled delivery of bioactive and sensitive food ingredients.
Phatthranit Klinmalai, Pitiya Kamonpatana, Atcharawan Srisa, Phanwipa Wongphan, Khwanchat Promhuad, Anusorn Seubsai, Nathdanai Harnkarnsujarit   +6 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Elimination Methods for High-Frequency Harmonics on the DC Side of Modular Multilevel Converters from the Perspective of Valve Control

Energies
Modular multilevel converter (MMC)-based HVDC systems have become one promising way to integrate a large amount of renewable energy. However, the high-frequency harmonics problem could seriously affect the safety and stable operation level of MMC-HVDCs ...
Qing Huai, Yirun Ji, Minxiang Yang, Ziyao Jie, Xi Yuan, Xiang Xu   +5 more
doaj   +1 more source