Results 51 to 60 of about 5,715 (244)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Epizootic Activity of Natural Plague Foci in the Territory of the Russian Federation in 2014 and Prognosis for 2015

Проблемы особо опасных инфекций, 2015
. Isolated were 128 plague agent strains: from rodents and lagomorphs - 24, 103 - from bloodsucking arthropods. One strain was obtained from a patient in the territory of Gorno-Altaisk high-mountain natural plague focus.
N. V. Popov, V. E. Bezsmertny, A. N. Matrosov, T. V. Knyazeva, A. A. Kuznetsov, Yu. M. Fedorov, V. P. Popov, D. B. Verzhutsky, V. M. Korzun, E. V. Chipanin, V. M. Dubyansky, O. V. Maletskaya, M. P. Grigor’Ev, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +15 more
doaj   +1 more source

Tailored Organogel Systems for Optimized Pesticide Delivery: Mechanistic Insights and Agricultural Applications

Advanced Science, EarlyView.
Utilizing molecular engineering for network design, three pesticide‐loaded organogels (PLOs) carriers exhibiting varying degrees of flexibility were prepared. The mechanical properties of these carriers, tunable via their network molecular structures, enhance their structural adaptability and retention stability at biological interfaces, thereby ...
Yue Wang, SiYu Xv, Chao Wu, Nan Li, GuoPeng Teng, XuePing Huang, Jian Luo   +6 more
wiley   +1 more source

Isozyme and allozyme markers distinguishing two morphologically similar, medically important Mastomys species (Rodentia: Muridae)

BMC Genetics, 2001
Background Two common southern African mice species, Mastomys coucha and M. natalensis, are widely distributed throughout the subregion and overlap in many areas.
Van der Bank Herman FH, Smit Andre A
doaj   +1 more source

Bird flu, avian influenza : the H5N1 virus, poultry, other animals, and people here and elsewhere, from Asia to Africa [PDF]

, 2006
Illustré d'une trentaine de photographies originales issues des missions de terrain des vétérinaires et ornithologues du Cirad dans les pays du Sud, le livret fait le point sur ce fléau qui a d'abord frappé les pays du Sud-Est asiatique depuis 1997 ...
Albina, Emmanuel, Balança, Gilles, Benmansour, Abdenour, Camus, Emmanuel, Cardinale, Eric, Caron, Alexandre, Chevalier, Véronique, De La Rocque, Stéphane, Desvaux, Stéphanie, Gaidet, Nicolas, Gerbier, Guillaume, Goutard, Flavie, Lancelot, Renaud, Martinez, Dominique, Monicat, François, Porphyre, Vincent, Renard, Jean-François, Richard, Didier, Roger, François, Salgado, Paulo, Vial, Laurence   +20 more
core  

Using detergent to enhance detection sensitivity of African trypanosomes in human CSF and blood by Loop-Mediated Isothermal Amplification (LAMP) [PDF]

, 2011
<p><b>Background:</b> The loop-mediated isothermal amplification (LAMP) assay, with its advantages of simplicity, rapidity and cost effectiveness, has evolved as one of the most sensitive and specific methods for the detection of a ...
A Johannessen, AJ Buckton, AP Cox, B Enanga, C Garrido, Dennis J. Grab, DJ Grab, E Matovu, E Pays, F Chappuis, F Hildebrandt, G Mlambo, GH Stresman, GJ Hafner, J Sambrook, J. Stephen Dumler, JA Inverso, Jayne Raper, K Kristensson, K Nagamine, Liam J. Morrison, LL Poon, M Koffi, M Radwanska, M Radwanska, N Kuboki, N Tomita, Noboru Inoue, Olga V. Nikolskaia, OM Thekisoe, OM Thekisoe, OM Thekisoe, OMM Thekisoe, Oriel M. M. Thekisoe, OV Nikolskaia, P Felgner, P Solano, PG Kennedy, PJ Mhando, R Docampo, S Bisser, S Deborggraeve, SL Wastling, T Notomi, Wendy Gibson, Y Eshita, Y Mori, Y Mori, YM Qiao, ZK Njiru, ZK Njiru, ZK Njiru, ZK Njiru, ZK Njiru, ZK Njiru   +54 more
core   +4 more sources

Structural Basis of the Membrane Association by the Conserved RocS Membrane‐Targeting Sequence in Streptococcus

Advanced Science, EarlyView.
Chromosome segregation in Streptococcus pneumoniae depends on RocS, a bitopic protein whose membrane‐anchoring mechanisms were unclear. Using NMR and AFM, this study reveals that the widely conserved RocS anchor binds to membranes via a conserved kink‐helix motif which inserts into lipid nanodomains.
Ana Álvarez‐Mena, Estelle Morvan, Clara Lambert, Anagha Kallisseri Parambil, Martin Lefeuvre, Zeren Xu, Nadia El Mammeri, Florian Malard, Erick J. Dufourc, Cécile Feuillie, Christophe Grangeasse, Birgit Habenstein   +11 more
wiley   +1 more source

Mucosal vaccines and technology [PDF]

, 2019
There is an urgent and unmet need to develop effective vaccines to reduce the global burden of infectious disease in both animals and humans, and in particular for the majority of pathogens that infect via mucosal sites. Here we summarise the impediments
Doavi T, European Commission, Grace DMF, Kantele A, Kathleen R, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization, World Health Organization (L’Organisation Mondiale de la Santé)   +12 more
core   +2 more sources

Spectroscopic Evidence of Edge‐Localized States in an Antiferromagnet Topological Insulator NdBi

Advanced Science, EarlyView.
Using spin‐polarized scanning tunneling microscopy (STM) in conjunction with quasiparticle interference, we successfully identify distinct signatures of the ferromagnetic and antiferromagnetic terminations in NdBi, a rare‐earth monopnictide exhibiting non‐trivial topology and magnetism. We demonstrate that step edges on ferromagnetic surfaces host well‐
Avior Almoalem, Rebecca Chan, Brinda Kuthanazhi, Juan Schmidt, Jose A. Moreno, Hermann Suderow, Paul Canfield, Taylor L. Hughes, Vidya Madhavan   +8 more
wiley   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, EarlyView.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source