Results 241 to 250 of about 11,339,765 (297)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

open access: yesFEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang   +10 more
wiley   +1 more source

On the evolution of carry‐over effects

Journal of Animal Ecology, 2019
AbstractThe environment experienced early in life often affects the traits that are developed after an individual has transitioned into new life stages and environments. Because the phenotypes induced by earlier environments are then screened by later ones, these ‘carry‐over effects’ influence fitness outcomes across the entire life cycle.While the ...
Michael P. Moore, Ryan A. Martin
openaire   +2 more sources

Robust and realistic approaches to carry‐over

Statistics in Medicine, 1998
The relationship between choice of model for carry-over and choice of efficient cross-over design is studied in particular with reference to two treatment designs in four periods and two sequences. The effect of model miss-specification is also examined. It is concluded that previous claims regarding efficient designs are not necessarily reasonable.
S, Senn, D, Lambrou
openaire   +2 more sources

The enigma of “carry-over”

International Rehabilitation Medicine, 1984
It is well known that after the cessation of treatment by functional electrical stimulation (FES) there is a continuation of the improvement of the muscle function "carry-over". If this could be harnessed and understood then this might lead to permanent improvement.
openaire   +2 more sources

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