Results 131 to 140 of about 323,350 (251)

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

On the carrying capacity of the bone marrow survival niche in mice. [PDF]

Front Immunol
Tonouchi K, Yeh CH, Cain DW, Moseman EA, Haynes BF, Wagh K, Wiehe K, Kurosaki T, Kelsoe G.   +8 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

The Influence of Thermal Conditions on the Stability and Load-Carrying Capacity of Compressed Thin-Walled Composite Profiles. [PDF]

Materials (Basel)
Debski H, Rozylo P, Kuciej M, Falkowicz K, Wysmulski P, Tomczyk A, Mazurek P.   +6 more
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Gompertz growth with a shared carrying capacity optimally simulates primary and metastatic tumor growth dynamics. [PDF]

Br J Cancer
Schlicke P, Korangath P, Pan X, Ercan C, Gabrielson K, Werhane L, Yuan Y, Benzekry S, Ivkov R, Enderling H.   +9 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Stoichiometric analysis of microbial communities links function, structure, and biomass carrying capacity. [PDF]

ISME J
Bruggeman FJ, Paez-Watson T, Teusink B, Kleerebezem R.   +3 more
europepmc   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Assessment of African grassland sustainability for livestock use by constructing a carrying capacity alert index. [PDF]

Nat Commun
Yu S, Zhang X, Liu Y, Yan N, Zhu W, Liu Y, Cheng Y, Yu X, Chen M, Zhang C, Jiang Y.   +10 more
europepmc   +1 more source