Results 161 to 170 of about 387,772 (298)

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

open access: yesAdvanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang   +7 more
wiley   +1 more source

Outcomes of bispecific antibodies after CAR T-cell failure for large B-cell lymphoma: results from the ABC consortium. [PDF]

open access: yesBlood Adv
Melody M   +29 more
europepmc   +1 more source

High‐Rate Cross‐Channel Entanglement Swapping Between Independent On‐Chip Sources

open access: yesAdvanced Science, EarlyView.
To interconnect individual chip‐based quantum sources, high‐performance entanglement swapping is indispensable. Here, using low‐loss silicon chips with waveguide structure and frequency‐offset pumps, this work demonstrates high‐rate cross‐channel entanglement swapping.
Haoyang Wang   +5 more
wiley   +1 more source

Serum Cocaine- and Amphetamine-Regulated Transcript Levels and Cooperativeness in Adolescents With Internet Gaming Disorder. [PDF]

open access: yesPsychiatry Investig
Lee H   +10 more
europepmc   +1 more source

Programmable Multifunctional Bistable Structures for Energy Transfer and Dissipation

open access: yesAdvanced Science, EarlyView.
Utilizing the energy conversion characteristics of asymmetric bistable beams, this study develops a programmable multifunctional system composed of multiple bistable beams for energy transfer and dissipation. The high energy density enables the system to demonstrate potential in transient scenarios such as target delivery and shock absorption ...
Xin Na   +6 more
wiley   +1 more source

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang   +9 more
wiley   +1 more source

Chronic alcohol consumption downregulates TRPA1 ion channel and the main peptidergic messengers of the Edinger-Westphal nucleus. [PDF]

open access: yesSci Rep
Al-Omari A   +11 more
europepmc   +1 more source

A Multifunctional Potent Lewis Acid for In Situ Formation of Poly‐Dioxolane Electrolytes Toward High‐Performance Quasi‐Solid State Lithium Metal Batteries

open access: yesAdvanced Science, EarlyView.
Conventional polymer electrolytes based on poly‐dioxolane (PDOL) suffer from low ion mobility and unstable interfaces. Here, AlCl3‐initiated in situ polymerized gel PDOL electrolytes (AGPE) form a facile Li+ conduction path and hybrid SEI layers, thus enabling high Li+ conductivity and uniform Li deposition.
Jaehyeong Yu   +6 more
wiley   +1 more source

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