Results 251 to 260 of about 151,261 (309)

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration

Small Structures, EarlyView.
This study successfully develops an injectable, dual‐function nanocomposite hydrogel comprising kartogenin‐loaded aminated hollow mesoporous Prussian blue (NH2‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). NH@K nanozyme rejuvenates the senescent microenvironment by scavenging reactive oxygen species and inhibiting ...
Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xu‐Ran Li, Qing‐Song Deng, Yu‐Chen Zhang, Ang Wang, Xiao‐Qiu Dou, Shang‐Chun Guo, Shi‐Cong Tao   +10 more
wiley   +1 more source

Exosome-Seeded Cryogel Scaffolds for Extracellular Matrix Regeneration in the Repair of Articular Cartilage Defects: An In Vitro and In Vivo Rabbit Model Study. [PDF]

Polymers (Basel)
Yang D, Yang J, Chang SJ, Hu JL, Chen YJ, Yang SW.   +5 more
europepmc   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Complete metamorphosis promotes morphological and functional diversity in Caudata

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Metamorphosis, a common and spectacular developmental process, involves major phenotypic changes often linked to environmental transitions. Understanding how these changes affect morphological evolution is crucial for examining metamorphosis's evolutionary impacts.
Vivien Louppe, Kevin Le Verger, Julien Clavel, Gabriel S. Ferreira, Christina Kyriakouli, Edward L. Stanley, Emily C. Watt, Carla Bardua, Celeste Pérez‐Ben, Nadia B. Fröbisch, Vivien Bothe, Renaud Boistel, Gheylen Daghfous, Anjali Goswami, Anne‐Claire Fabre   +14 more
wiley   +1 more source

Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression. [PDF]

J Orthop Surg Res
Gao Y, Wang K, Shi C, Gao Y, Kong DQ.
europepmc   +1 more source

Artemisinins in autoimmune diseases: effects and mechanisms in systemic lupus erythematosus and rheumatoid arthritis

British Journal of Pharmacology, EarlyView.
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) result from immune self‐tolerance loss, causing tissue damage. Standard treatments targeting late‐stage inflammation often have serious side effects. Artemisinin, known for its antimalarial properties, shows potential immunomodulatory effects.
Fanchao Zhou, Guoming Li, Ruixiang Tan, Guodong Wu, Changsheng Deng   +4 more
wiley   +1 more source

Genotypic and Phenotypic Characterization of Seven Individuals With Predicted Bone Morphogenetic Protein 2 (BMP2) Haploinsufficiency

Clinical Genetics, EarlyView.
BMP2 haploinsufficiency is known to be associated with short stature, skeletal malformations, specific craniofacial traits and cardiac malformations. This study including individuals with predicted BMP2 haploinsufficiency provides additional insight regarding less established and sometimes controversial phenotypes such as degree of developmental delay,
Elin Stavrén‐Eriksson, Anna Hammarsjö, Anna Lindstrand, Ann Nordgren, Giedre Grigelioniene, Maritta Hellström Pigg   +5 more
wiley   +1 more source

Matrix stiffness in osteoarthritis: from mechanism introduction to biomaterial-based therapies. [PDF]

Front Endocrinol (Lausanne)
Huang K, Cai H.
europepmc   +1 more source

Exploring the Therapeutic Potential of MIR‐140‐3p in Osteoarthritis: Targeting CILP and Ferroptosis for Novel Treatment Strategies

Cell Proliferation, EarlyView.
Global landscape. ABSTRACT Osteoarthritis (OA) is a prevalent and debilitating joint disorder that affects millions of individuals worldwide, severely impairing mobility, independence, and quality of life. Emerging evidence suggests that ferroptosis is a critical factor in OA pathogenesis.
Feng Ma, Lexin Wang, Hao Chi, Xinyi Li, Yaoqin Xu, Kexin Chen, Jingfan Zhou, Runqin Yang, Jie Liu, Ke Xu, Xiaoling Yang   +10 more
wiley   +1 more source

Evaluation of the Influence of Changes in Bone Mineral Density and Increases in Articular Cartilage Thickness on Blood Supply of the Femoral Head in Legg-Calvé-Perthes Disease. [PDF]

Hip Pelvis
Farpour HR, Karimi MT, Karimi MH.
europepmc   +1 more source