Results 131 to 140 of about 310,417 (319)

Cartilage-targeting dexamethasone prodrugs increase the efficacy of dexamethasone

, 2018
Florian A. Formica, Gonçalo Barreto, Marcy Zenobi‐Wong   +2 more
openalex   +2 more sources

Biodegradable Zn‐Based Implants: Progress, Challenges, and Pathways toward Clinical Translation

Advanced Science, EarlyView.
Exploring biodegradable Zn‐based implants offers a promising pathway to next‐generation biomedical devices with balanced degradation and biocompatibility. A comprehensive overview of biodegradable Zn‐based implants, covering their biological significance, material design principles, and advanced engineering strategies is provided.
Panfeng Zhao, Zhengquan Wang, Hui Yang, Xiyuan Zhang, Hanyuan Liu, Xiaotong Lu, Xiaocheng Li, Yanyan Liu, Xi Zhao, Wenhao Zhou, Yufeng Zheng   +10 more
wiley   +1 more source

Finite element prediction of cartilage contact stresses in normal human hips [PDF]

, 2011
Michael D. Harris, Andrew E. Anderson, Corinne R. Henak, Benjamin J. Ellis, Christopher L. Peters, Jeffrey A. Weiss   +5 more
openalex   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Quantification of cartilage biomechanical and biochemical properties via T_1ρ magnetic resonance imaging [PDF]

, 2005
Andrew J. Wheaton, George R. Dodge, Dawn M. Elliott, Steven B. Nicoll, Ravinder Reddy   +4 more
openalex   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Corrigendum: NF-κB/TWIST1 Mediates Migration and Phagocytosis of Macrophages in the Mice Model of Implant-Associated Staphylococcus aureus Osteomyelitis

Frontiers in Microbiology, 2020
Yutian Wang, Yutian Wang, Yihuang Lin, Yihuang Lin, Caiyu Cheng, Caiyu Cheng, Pengyu Chen, Pengyu Chen, Ping Zhang, Hangtian Wu, Hangtian Wu, Kaiqun Li, Kaiqun Li, Ye Deng, Ye Deng, Jikun Qian, Jikun Qian, Xianrong Zhang, Xianrong Zhang, Bin Yu, Bin Yu   +20 more
doaj   +1 more source

Tissue engineering for articular cartilage repair – the state of the art

, 2013
Brian Johnstone, Mauro Alini, Magali Cucchiarini, GR Dodge, David Eglin, Farshid Guilak, Henning Madry, Álvaro Mata, Robert L. Mauck, CE Semino, Martin J. Stoddart   +10 more
openalex   +1 more source

Identification of long non-coding RNAs expressed in knee and hip osteoarthritic cartilage [PDF]

, 2019
Bola Ajekigbe, Kathleen Cheung, Yaobo Xu, Andrew Skelton, Andreas Panagiotopoulos, Jamie Soul, Tim Hardingham, David J. Deehan, Matt J. Barter, David A. Young   +9 more
openalex   +1 more source

Vascularization of tissue engineered cartilage - Sequential in vivo MRI display functional blood circulation

, 2021
Peter Apelgren, Matteo Amoroso, Karin Säljö, Mikael Montelius, Anders Lindahl, Linnéa Stridh Orrhult, Paul Gatenholm, Lars Kölby   +7 more
openalex   +1 more source