Results 241 to 250 of about 534,378 (337)

THE EXTRACELLULAR AND INTRACELLULAR WATER IN BONE AND CARTILAGE

, 1938
Vivian Iob, W.W. Swanson
openalex   +1 more source

Next‐Generation Piezoelectric Materials in Wearable and Implantable Devices for Continuous Physiological Monitoring

Advanced Science, EarlyView.
An analysis of literature trends and a historical overview of organic and inorganic piezoelectric materials, focusing on their structural diversity, functional mechanisms, and inherent characteristics. It then explores cutting‐edge developments in material synthesis, fabrication processes, and performance optimization, highlighting their applicability ...
Bangul Khan, Umay Amara, Bilawal Khan, Wasim Ullah Khan, Rafi u Shan Ahmad, Muhammad Shehzad Khan, Mohamed Elhousseini Hilal, Bee Luan Khoo   +7 more
wiley   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

Advanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang, Yuxiao Wang, Yang Ding, Xiang Chen, Shuhan Li, Wenqi Zhou, Rui Ma, Maomao Tang, Xinyuan Shao, Zixuan Shu, Ning He, Xiaodong Ma, Jian Guo, Chengjun Peng, Shuangying Gui   +14 more
wiley   +1 more source

Tumor‐Tissue Boundaries as Instructive Interfaces in Breast Cancer Cell Invasion

Advanced Science, EarlyView.
Tumor‐tissue boundaries reprogram metastatic breast cancer cells, enhancing invasiveness through an instructive, not permissive, mechanism. Using a 3D collagen I‐based tumor‐tissue interface model, single‐cell analysis, and simulations, this study shows that all cells can transmigrate without selective filtering, highlighting a targetable process in ...
Cornelia Clemens, Thomas Zerjatke, Andrine Frank, Hannah Trampert, Nataliia Kotsiuba, Ingmar Glauche, Tilo Pompe   +6 more
wiley   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, EarlyView.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Magnetized Cell‐Scaffold Constructs for Bone Tissue Engineering: Advances in Fabrication and Magnetic Stimulation

Advanced Science, EarlyView.
This review highlights the synthesis and applications of magnetized cells (MCs) and magnetized scaffolds (MSs) in advancing bone tissue engineering strategies. It further demonstrates how magnetic particles (MPs) improve scaffold properties and how external magnetic fields enhance mesenchymal stem cell adhesion, proliferation, and osteogenic ...
Elio Cinar SanSegundo, Mohammad J. Mirzaali, Lidy E. Fratila‐Apachitei, Amir A. Zadpoor   +3 more
wiley   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
wiley   +1 more source

Rabbits as preclinical animal models of cam morphology: proof of concept. [PDF]

BMC Musculoskelet Disord
Li Z, Wan P, Liu X, Jiang G, Li J, Chen D, Zhang W, Tian K.   +7 more
europepmc   +1 more source