Results 151 to 160 of about 337,591 (267)

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Plant UBX domain-containing proteins use distinct strategies to stably engage the unfoldase CDC48A. [PDF]

Plant Cell Physiol
Zhang J, Wang J, Sandholu A, Shahul Hameed UF, Arold ST.   +4 more
europepmc   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Should I play or should I watch: the effects of active and passive distraction methods on children's pain, fear and anxiety during invasive procedures: a randomized controlled clinical trial. [PDF]

BMC Pediatr
Gökoğlu A, Sukut Ö.
europepmc   +1 more source

An Unfolding Story: AlphaFold's View on Protein Flexibility

Helvetica Chimica Acta, EarlyView.
AlphaFold confidence measures allow for detailed proteome‐wide characterization of protein flexibility. All flexibility measures increased substantially in the evolutionary transition from prokaryota to eukaryota. ABSTRACT The AlphaFold confidence measures are related to conformation distribution of the protein.
Gunnar Jeschke
wiley   +1 more source

Structural basis of dimerization and cascade formation by Cas5. [PDF]

Sci Rep
Kang YJ, Ha HJ, Jin HB, Lee SY, Park HH.
europepmc   +1 more source

The A(I) Team: Effects of Human‐Likeness and Conformity to Gender Stereotypes on Initial Trust and Willingness to Work With an AI Teammate

Journal of Organizational Behavior, EarlyView.
ABSTRACT As artificial intelligence (AI) technologies progress, AI agents arise as potential teammates in the workplace. This study explores how the visual representation of the AI agent as well as its conformity to traditional gender stereotypes affects the manifestation of uncanny valley effects in a workplace team context.
Agata Mirowska, Jbid Arsenyan
wiley   +1 more source

The Development of Temporal Memory for Complex Events. [PDF]

Dev Sci
Frisoni M, Pedale T, Capurso M, Santangelo V, Sestieri C.   +4 more
europepmc   +1 more source

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

A study on the mechanism of Buyang Huanwu Decoction in treating epilepsy by regulating adenosine levels. [PDF]

Sci Rep
Wu S, Deng Y, Yang J, Peng Z, Chen J.
europepmc   +1 more source