Results 141 to 150 of about 17,056 (307)

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

open access: yesAngewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran   +11 more
wiley   +1 more source

Visualizing War

open access: yes, 2012
Popular artwork during the era of the Civil war can be placed into three broad categories. The first is a prewar theme of political discontent, in which political leaders were viewed as ineffective and ill-prepared to address the political challenges of ...
Egbert, Andrew
core  

An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice

open access: yesThe Anatomical Record, EarlyView.
An elastic segment was found in the basal part of the whisker shaft in rats and mice. Application of force to the whisker bulb of isolated follicles caused bending and twisting of this segment. Active whisker movements deform this segment, causing whisker shaft deflection and selective activation of mechanoreceptors at different phases of whisking ...
Sebastian Haidarliu   +4 more
wiley   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

open access: yesAnimal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang   +11 more
wiley   +1 more source

Autistic Children With Speech Onset Delay Show Reversed Bias in Spectral Versus Temporal Auditory Processing

open access: yesAutism Research, EarlyView.
ABSTRACT A recent “hierarchical” reinterpretation of the neurological basis of autism suggests that in autism with early language delay, perceptual processing may be favored over the integration of transmodal information. This model is largely based on neuroimaging findings relating to visual processing, but predicts a corresponding reorganization in ...
Luodi Yu   +3 more
wiley   +1 more source

Event‐ and Time‐Based Prospective Memory and Time Perception in Autistic Adults With and Without Intellectual Disabilities

open access: yesAutism Research, EarlyView.
ABSTRACT The aim of this study was to examine time perception (i.e., the sense of the duration, order and passage of time) and event‐ and time‐based prospective memory (PM; i.e., the ability to recall an intention to perform an action in the future) in adults across the wider autism spectrum including those with intellectual disabilities.
Daniela Nürnberg, Mareike Altgassen
wiley   +1 more source

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